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Amisulpride is an atypical antipsychotic that acts as an antagonist at 5-HT7 receptors and D2/3 receptors. Amisulpride also exhibits neuroprotective activity, modulating β2-arrestin signaling to increase phosphorylation of Akt and GSK-3β, increasing neurite outgrowth in vitro.
| Cas No. | 71675-85-9 |
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| Purity | ≥98% |
| Formula | C17H27N3O4S |
| Formula Wt. | 369.48 |
| IUPAC Name | 4-amino-N-[(1-ethylpyrrolidin-2-yl)methyl]-5-ethylsulfonyl-2- methoxybenzamide |
| Melting Point | 126-127C |
| Solubility | Ethanol (1 mg/ml), DMSO (15 mg/ml), DMF (15 mg/ml) |
| Appearance | White to off white powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Meltzer HY. Serotonergic mechanisms as targets for existing and novel antipsychotics. Handb Exp Pharmacol. 2012;(212):87-124. PMID: 23129329.
Park SW, Seo MK, Cho HY, et al. Differential effects of amisulpride and haloperidol on dopamine D2 receptor-mediated signaling in SH-SY5Y cells. Neuropharmacology. 2011 Sep;61(4):761-9. PMID: 21663752.
Möller HJ. Amisulpride: limbic specificity and the mechanism of antipsychotic atypicality. Prog Neuropsychopharmacol Biol Psychiatry. 2003 Oct;27(7):1101-11. PMID: 14642970.