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Pazufloxacin is a fluoroquinolone antibiotic that exhibits antibacterial efficacy against species of Legionella, Staphylococcus, Streptococcus, Gardnerella, Escherichia, Pseudomonas, and Bacteriodes. Pazufloxacin inhibits topoisomerase IV and DNA gyrase.
| Cas No. | 163680-77-1 |
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| Purity | ≥98% |
| Formula | C16H15FN2O4 • CH3SO3H |
| Formula Wt. | 414.41 |
| Chemical Name | (3S)-10-(1-Aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6- carboxylic acid |
| IUPAC Name | (2S)-6-(1-aminocyclopropyl)-7-fluoro-2-methyl-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid;methanesulfonic acid |
| Synonym | Pazufloxacin mesylate |
| Melting Point | 258-259°C (dec) |
| Solubility | Soluble in water. |
| Appearance | White or Light Yellow Powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Higa F, Akamine M, Haranaga S, et al. In vitro activity of pazufloxacin, tosufloxacin and other quinolones against Legionella species. J Antimicrob Chemother. 2005 Dec;56(6):1053-7. PMID: 16260445.
Takei M, Fukuda H, Kishii R, et al. Target preference of 15 quinolones against Staphylococcus aureus, based on antibacterial activities and target inhibition. Antimicrob Agents Chemother. 2001 Dec;45(12):3544-7. PMID: 11709337.
Mikamo H, Sato Y, Hayasaki Y, et al. In vitro activities of pazufloxacin, a novel injectable quinolone, against bacteria causing infections in obstetric and gynecological patients. Chemotherapy. 1999 May-Jun;45(3):154-7. PMID: 10224336.