LKT Labs

Biochemicals for Life Science Research

Tedizolid

Product ID T165131
Cas No. 856866-72-3
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $102.10 In stock
25 mg $340.70 In stock
100 mg $885.70 In stock
Bulk Quote

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Description

Tedizolid is a second-generation oxazolidinone found to be effective against gram-positive pathogens. In murine models of penicillin-resistant Streptococcus pneumoniae infection, tedizolid was as effective as or more effective than linezolid and showed less inflammatory cell invasion into alveolar spaces. In another study on a murine model of hematogenous pulmonary infection, tedizolid and linezolid both showed antimicrobial and immunomodulatory results superior to treatment with vancomycin.

Product Info

Cas No.

856866-72-3
Purity

≥98%

Formula

C17H15FN6O3
Formula Wt.

370.34
Chemical Name

3-(3-fluoro-4-(6-(2-methyl-2H-tetrazol-5-yl)pyridin-3-yl)phenyl)-5-(hydroxymethyl)oxazolidin-2-one
IUPAC Name

(5R)-3-{3-Fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)-3-pyridinyl]phenyl}-5-(hydroxymethyl)-1,3-oxazolidin-2-one
Synonym

TR 700
Solubility

Soluble in Dimethyl sulfoxide,10 mM in DMSO

Shipping and Storage

Store Temp

-20°C
Ship Temp

Blue Ice

Downloads

MSDS

T165131 MSDS PDF
Info Sheet

T165131 Info Sheet PDF

References

Choi S, Im W, Bartizal K. Activity of tedizolid phosphate (TR-701) in murine models of infection with penicillin-resistant and penicillin-sensitive Streptococcus pneumoniae. Antimicrob Agents Chemother. 2012 Sep;56(9):4713-4717. PMID: 22713339.

Kaku N, Morinaga Y, Takeda K, et al. Antimicrobial and immunomodulatory effects of tedizolid against methicillin-resistant Staphylococcus aureus in a murine model of hematogenous pulmonary infection. Int J Med Microbiol. 2016 Sep;306(6):421-428. PMID: 27259840.

Park KH, Greenwood-Quaintance KE, Mandrekar J, et al. Activity of tedizolid in methicillin-resistant Staphylococcus aureus experimental foreign body-associated osteomyelitis. Antimicrob Agents Chemother. 2016 Oct 21;60(11):6568-6572. PMID: 27550347.

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