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Bifonazole

Product ID B3320
Cas No. 60628-96-8
Purity ≥98%
Product Unit SizeCostQuantityStock
1 g $47.60 In stock
5 g $118.90 In stock
25 g $382.50 In stock
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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Bifonazole is an imidazole antifungal that also exhibits anticancer activity. Bifonazole inhibits calmodulin, HMG-CoA reductase, and 14-α demethylase in fungi such as dermatophytes. Bifonazole also decreases cell viability and induces Ca2+-dependent apoptosis in prostate cancer cells and melanoma cells.

Product Info

Cas No.

60628-96-8

Purity

≥98%

Formula

C22H18N2

Formula Wt.

310.39

Chemical Name

1-([1,1'-Biphenyl]-4-yl-phenylmethyl)-1H-imidazole

IUPAC Name

1-[phenyl-(4-phenylphenyl)methyl]imidazole

Synonym

Amycor, Bedriol, Mycospor, Mycosporan

Melting Point

142°C

Solubility

Soluble in alcohols, DMF or DMSO.

Appearance

White or Almost White Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

B3320 MSDS PDF

Info Sheet

B3320 Info Sheet PDF

References

Cheng JS, Chou CT, Liang WZ, et al. The mechanism of bifonazole-induced [Ca2+]i rises and non-Ca2+-triggered cell death in PC3 human prostate cancer cells. J Recept Signal Transduct Res. 2014 May 22:1-7. PMID: 24849495.

Penso J, Beitner R. Clotrimazole and bifonazole detach hexokinase from mitochondria of melanoma cells. Eur J Pharmacol. 1998 Jan 19;342(1):113-7. PMID: 9544799.

Hegemann L, Toso SM, Lahijani KI, et al. Direct interaction of antifungal azole-derivatives with calmodulin: a possible mechanism for their therapeutic activity. J Invest Dermatol. 1993 Mar;100(3):343-6. PMID: 8440921.

Berg D, Regel E, Harenberg HE, et al. Bifonazole and clotrimazole. Their mode of action and the possible reason for the fungicidal behaviour of bifonazole. Arzneimittelforschung. 1984;34(2):139-46. PMID: 6372801.

Kawakami K, Harada T, Yoshihashi Y, et al. Correlation between glass-forming ability and fragility of pharmaceutical compounds. J Phys Chem B. 2015 Apr 9;119(14):4873-4880. PMID: 25781503.

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