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Marbofloxacin is a fluoroquinolone antibiotic commonly used in veterinary medicine. Originally developed to treat gram negative bacterial infections, marbofloxacin exhibits antibacterial activity against a broad spectrum of bacteria, including species of Staphylococcus, Escherichia, Actinobacillus, Pasturella, and Mannheima. Marbofloxacin exerts its activity through inhibition of bacterial DNA gyrase.
| Cas No. | 115550-35-1 |
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| Purity | ≥98% |
| Formula | C17H19FN4O4 |
| Formula Wt. | 362.36 |
| Chemical Name | 9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-piperazino)-7-oxo-7H-pyrido[1,2,3-ij][1,2,4]benzoxadiazine-6-carboxylic acid |
| IUPAC Name | 9-Fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-[1,3,4]oxadiazino[6,5,4-ij]quinoline-6-carboxylic acid |
| Synonym | Zeniquin |
| Melting Point | 268-269°C |
| Appearance | Yellow Powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Damte D, Lee SJ, Yohannes SB, et al. Comparative activities of selected fluoroquinolones against dynamic populations of Actinobacillus pleuropneumoniae in an in vitro model of time-kill continuous culture experiment. Int J Antimicrob Agents. 2013 Dec;42(6):544-52. PMID: 24139884.
Illambas J, Potter T, Cheng Z, et al. Pharmacodynamics of marbofloxacin for calf pneumonia pathogens. Res Vet Sci. 2013 Jun;94(3):675-81. PMID: 23375665.
Awji EG, Tassew DD, Lee JS, et al. Comparative mutant prevention concentration and mechanism of resistance to veterinary fluoroquinolones in Staphylococcus pseudintermedius. Vet Dermatol. 2012 Aug;23(4):376-80, e68-9. PMID: 22409306.
Gebru E, Choi MJ, Lee SJ, et al. Mutant-prevention concentration and mechanism of resistance in clinical isolates and enrofloxacin/marbofloxacin-selected mutants of Escherichia coli of canine origin. J Med Microbiol. 2011 Oct;60(Pt 10):1512-22. PMID: 21596912.
Spreng M, Deleforge J, Thomas V, et al. Antibacterial activity of marbofloxacin. A new fluoroquinolone for veterinary use against canine and feline isolates. J Vet Pharmacol Ther. 1995 Aug;18(4):284-9. PMID: 8583541.
