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Clarithromycin is a macrolide antibiotic that binds 23S rRNA on the bacterial 50S ribosomal subunit, inhibiting protein translation and synthesis. Clarithromycin is clinically used to treat respiratory infections and displays efficacy primarily against gram positive bacteria and Helicobacter pylori.
| Cas No. | 81103-11-9 |
|---|---|
| Purity | ≥95% |
| Formula | C38H69NO13 |
| Formula Wt. | 747.95 |
| Chemical Name | 6-O-Methylerythromycin |
| IUPAC Name | (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-[(2S,3R,4S, 6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-12, 13-dihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4, 6-dimethyloxan-2-yl]oxy-7-methoxy-3,5,7,9,11, 13-hexamethyl-oxacyclotetradecane-2,10-dione |
| Synonym | Biaxin, Cyllind, Klacid, Macladin, Naxy, Veclam, Zeclar |
| Melting Point | 217-220°C (dec) |
| Solubility | Soluble in acetone, DMSO (18mg/mL). |
| Appearance | White Crystal Powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Cobos-Trigueros N, Ateka O, Pitart C, et al. Macrolides and ketolides. Enferm Infecc Microbiol Clin. 2009 Aug-Sep;27(7):412-8. PMID: 19625112.
Hao Q, Li Y, Zhang ZJ, et al. New mutation points in 23S rRNA gene associated with Helicobacter pylori resistance to clarithromycin in northeast China. World J Gastroenterol. 2004 Apr 1;10(7):1075-7. PMID: 15052698.
