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S-Sulforaphane is a synthetic isothiocyanate. The R isomer of sulforaphane is found in broccoli. Sulforaphane is an inducer of phase II enzymes, displaying antioxidative and chemopreventive activities. It may inhibit the aryl hydrocarbon receptor (AhR).
| Cas No. | 155320-20-0 |
|---|---|
| Purity | ≥97% |
| Formula | C6H11NOS2 |
| Formula Wt. | 177.29 |
| Chemical Name | 1-Isothiocyanato-4[(S)-(methylsulfinyl)]-butane |
| IUPAC Name | 1-isothiocyanato-4-[(S)-methylsulfinyl]butane |
| Synonym | D-Sulforaphane; S(+)-sulforaphane |
| Solubility | Soluble in ethanol, methanol, or ethyl acetate. Miscible with water and/or DMSO. |
| Appearance | Slightly yellowish liquid |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
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Abdull Razis AF, Hanlon N, Soltys E, et al. The naturally occurring aliphatic isothiocyanates sulforaphane and erucin are weak agonists but potent non-competitive antagonists of the aryl hydrocarbon receptor. Arch Toxicol. 2012 Oct;86(10):1505-14. PMID: 22643862.
Abdull Razis AF, Bagatta M, De Nicola GR, et al. Induction of epoxide hydrolase and glucuronosyl transferase by isothiocyanates and intact glucosinolates in precision-cut rat liver slices: importance of side-chain substituent and chirality. Arch Toxicol. 2011 Aug;85(8):919-27. PMID: 21132492.
Christine A. Houghton, Sulforaphane: Its “Coming of Age” as a Clinically Relevant Nutraceutical in the Prevention and Treatment of Chronic Disease. Oxidative Medicine and Cellular Longevity Volume 2019, Article ID 2716870, 27 pages https://doi.org/10.1155/2019/2716870