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Paliperidone

Paliperidone

Product ID P0144
Cas No. 144598-75-4
Purity ≥97%
Product Unit SizeCostQuantityStock
25 mg $126.50 In stock
100 mg $360.70 In stock
500 mg $1,323.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Paliperidone is an antipsychotic compound that inhibits D2 receptors and 5-HT2A receptors and is used to treat schizophrenia. Paliperidone also attenuates epinephrine- and serotonin-induced platelet aggregation.

Product Info

Cas No.

144598-75-4

Purity

≥97%

Formula

C23H27FN4O3

Formula Wt.

426.48

IUPAC Name

3-[2-[4-(6-fluoro-1, 2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-9-hydroxy-2-methyl-6,7,8, 9-tetrahydropyrido[1,2-a]pyrimidin-4-one

Synonym

3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one, 9-OH-risperidone

Melting Point

158-160°C

Solubility

DMSO: >5 mg/mL

Appearance

An offwhite or pale yellow powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

P0144 MSDS PDF

Info Sheet

P0144 Info Sheet PDF

References

Kozielska M, Johnson M, Pilla Reddy V, et al. Pharmacokinetic-pharmacodynamic modeling of the D2 and 5-HT (2A) receptor occupancy of risperidone and paliperidone in rats. Pharm Res. 2012 Jul;29(7):1932-48. PMID: 22437487.

Gilday E, Nasrallah HA. Clinical pharmacology of paliperidone palmitate a parenteral long-acting formulation for the treatment of schizophrenia. Rev Recent Clin Trials. 2012 Feb;7(1):2-9. PMID: 22023179.

De Clerck F, Somers Y, Mannaert E, et al. In vitro effects of risperidone and 9-hydroxy-risperidone on human platelet function, plasma coagulation, and fibrinolysis. Clin Ther. 2004 Aug;26(8):1261-73. PMID: 15476907.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
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  • This field is for validation purposes and should be left unchanged.

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