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NVP-HDM201

Product ID N859610
Cas No. 1448867-41-1
Purity ≥99%
Product Unit SizeCostQuantityStock
1 mg $85.00 In stock
5 mg $175.00 In stock
10 mg $275.00 In stock
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  • Description
  • Product Info
  • Shipping and Storage
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  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

NVP-HDM201 is a selective inhibitor of the MDM2-p53 interaction

Product Info

Cas No.

1448867-41-1

Purity

≥99%

Formula

C26H24Cl2N6O4

IUPAC Name

(4S)-5-(5-chloro-1-methyl-2-oxopyridin-3-yl)-4-(4-chlorophenyl)-2-(2,4-dimethoxypyrimidin-5-yl)-3-propan-2-yl-4H-pyrrolo[3,4-d]imidazol-6-one

Synonym

Siremadlin; HDM-201

Appearance

White crystalline powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

Info Sheet

N859610 Info Sheet PDF

References

Wu C, Huang C, Chen C, et al. WIP1 inhibition by GSK2830371 potentiates HDM201 through enhanced p53 phosphorylation and activation in liver adenocarcinoma cells. Cancers (Basel). 2021 Jul 31;13(15):3876. PMID: 34359777

Wang H, Mulford I, Sharp F, et al. Inhibition of MDM2 promotes antitumor responses in p53 wild-type cancer cells through their interaction with the immune and stromal microenvironment. Cancer Res. 2021 Jun 1;81(11):3079-3091. PMID: 33504557

Vaupel A, Holzer P, Ferretti S, et al. In vitro and in vivo characterization of a novel, highly potent p53-MDM2 inhibitor. Bioorg Med Chem Lett. 2018 Nov 1;28(20):3404-3408. PMID: 30217415

Custom Order

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