Description
NVP-HDM201 is a selective inhibitor of the MDM2-p53 interaction
Product Unit Size | Cost | Quantity | Stock |
---|
NVP-HDM201 is a selective inhibitor of the MDM2-p53 interaction
Cas No. | 1448867-41-1 |
---|---|
Purity | ≥99% |
Formula | C26H24Cl2N6O4 |
IUPAC Name | (4S)-5-(5-chloro-1-methyl-2-oxopyridin-3-yl)-4-(4-chlorophenyl)-2-(2,4-dimethoxypyrimidin-5-yl)-3-propan-2-yl-4H-pyrrolo[3,4-d]imidazol-6-one |
Synonym | Siremadlin; HDM-201 |
Appearance | White crystalline powder |
Store Temp | -20°C |
---|---|
Ship Temp | Ambient |
Info Sheet |
---|
Wu C, Huang C, Chen C, et al. WIP1 inhibition by GSK2830371 potentiates HDM201 through enhanced p53 phosphorylation and activation in liver adenocarcinoma cells. Cancers (Basel). 2021 Jul 31;13(15):3876. PMID: 34359777
Wang H, Mulford I, Sharp F, et al. Inhibition of MDM2 promotes antitumor responses in p53 wild-type cancer cells through their interaction with the immune and stromal microenvironment. Cancer Res. 2021 Jun 1;81(11):3079-3091. PMID: 33504557
Vaupel A, Holzer P, Ferretti S, et al. In vitro and in vivo characterization of a novel, highly potent p53-MDM2 inhibitor. Bioorg Med Chem Lett. 2018 Nov 1;28(20):3404-3408. PMID: 30217415
NSAID; COX-1/2 inhibitor.
p110δ PI3K inhibitor.
ROCK inhibitor.
EGFR inhibitor.
Kavalactone originally found in Piper methystic...
Saponin found in Bupleurum, Heteromorpha, and S...
Mycotoxin produced by Fusarium; sphingosine acy...
EZH2 inhibitor
Arp2/3 inhibitor.
Fungal metabolite produced by Penicillium speci...
EGFR inhibitor.
ITC, erucin analog.
Flavanol originally found in Camilla (green tea...
Flavanol originally found in Camilla (green tea...
Antimicrobial peptide found in bee and wasp ven...
FK506 analog; calcineurin inhibitor.
AT-II antagonist, PPARγ/δ modulator.
Cysteine-ITC conjugate.
Catalyzes hydrolysis of asparagine.
Imidazoquinazoline; PDE3 inhibitor.