Description
Docetaxel is a taxane that exhibits anticancer chemotherapeutic activity. Docetaxel is a semi-synthetic analog of taxol that displays a similar mechanism of action, acting as an antimitotic by inhibiting microtubule depolymerization.
Product Info
| Cas No. | 114977-28-5 |
|---|---|
| Purity | ≥98% |
| Formula | C43H53NO14 |
| Formula Wt. | 807.89 |
| Chemical Name | (αR,βS)-β-[[(1,1-Dimethylethoxy)carbonyl]amino]-α-hydroxybenzenepropanoic acid (2aR,4S,4aS,6R,9S,- 11S,12S,12aR,12bS)-12b-(acetyloxy)-12(benzoyloxy)- 2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11- trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester |
| Synonym | N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol, Taxotere |
| Melting Point | 186-190°C |
| Solubility | Soluble in DMSO, ethanol, chloroform, dichloromethane, ethyl acetate, methanol. Insoluble in water. |
| Appearance | White or off-white powder |
Shipping and Storage
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
Downloads
| MSDS | |
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| Info Sheet |
References
Lyseng-Williamson KA, Fenton C. Docetaxel: a review of its use in metastatic breast cancer. Drugs. 2005;65(17):2513-31. PMID: 16296875.
Eisenhauer EA, Vermorken JB. The taxoids. Comparative clinical pharmacology and therapeutic potential. Drugs. 1998 Jan;55(1):5-30. PMID: 9463787.