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Leptomycin B

Leptomycin B

Product ID L1761
Cas No. 87081-35-4
Purity ≥98%
Product Unit SizeCostQuantityStock
10 µg $68.30 In stock
50 µg $157.50 In stock
1 mg $199.50 In stock
5 mg $315.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Leptomycin is a polyketide antibiotic initially produced by Streptomyces. Leptomycin exhibits anticancer and antifungal activity. Leptomycin inhibits CRM1, preventing nuclear export of proteins. In lung cancer cells, leptomycin induces G1 phase cell cycle arrest; in cervical carcinoma cells, leptomycin increases activation of p53, inducing apoptosis.

Product Info

Cas No.

87081-35-4

Purity

≥98%

Formula

C33H48O6

Formula Wt.

540.74

Chemical Name

19-(3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-8-oxo- 2,10,12,16,18-Nonadecapentaenoic acid

IUPAC Name

(2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-17-ethyl-6-hydroxy-3,5,7,9,11, 15-hexamethyl-19-[(2R,3S)-3-methyl-6-oxo-2, 3-dihydropyran-2-yl]-8-oxononadeca-2,10,12,16,18-pentaenoic acid

Synonym

LMB, Elactocin, CI-940, CL-1957A, NSC-364372, PD-114720.

Melting Point

41-44°C

Solubility

Soluble in ethanol or methanol.

Appearance

Clear colorless solution in absolute EtOH OR Slight yellow solid

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

L1761 MSDS PDF

Info Sheet

L1761 Info Sheet PDF

References

Sun Q, Carrasco YP, Hu Y, et al. Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1. Proc Natl Acad Sci U S A. 2013 Jan 22;110(4):1303-8. PMID: 23297231.

Abkallo HM, Kawano H, Watanabe K, et al. A new cell-based reporter system for sensitive screening of nuclear export inhibitors. Drug Discov Ther. 2011 Dec;5(6):286-92. PMID: 22466439.

Lu C, Shao C, Cobos E, et al. Chemotherapeutic sensitization of leptomycin B resistant lung cancer cells by pretreatment with doxorubicin. PLoS One. 2012;7(3):e32895. PMID: 22412944.

Hamamoto T, Gunji S, Tsuji H, et al. Leptomycins A and B, new antifungal antibiotics. I. Taxonomy of the producing strain and their fermentation, purification and characterization. J Antibiot (Tokyo). 1983 Jun;36(6):639-45. PMID: 6874585.

Custom Order

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