Oridonin is a diterpenoid found in Rabdosia rubescens. Oridonin has anti-inflammatory and antibacterial activity but is most widely known for its anticancer chemotherapeutic actions. This compound can bind HPS70 1A and can fit into the DNA double helix, provoking p53-mediated G2/M cell cycle arrest, apoptosis, and autophagy; these effects inhibit tumor growth in a wide variety of cell lines.
| Cas No. | 28957-04-2 |
|---|---|
| Purity | ≥98% |
| Formula | C20H28O6 |
| Formula Wt. | 364.43 |
| Chemical Name | 7a,20-Epoxy-1a,6b,7,14-tetrahydroxy-Kaur-16-en-15-one |
| Synonym | Isodonol, Rubescensin A (high purity) |
| Solubility | DMSO 72 mg/mL (197.56 mM) Ethanol 28 mg/mL (76.83 mM) Water Insoluble |
| Appearance | White to off white powder |
| Store Temp | 4°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | |
|---|---|
| Info Sheet |
Chen Z, Wang Z, Chen J, et al. Resonance light scattering technique as a new tool to determine the binding mode of anticancer drug oridonin to DNA. Eur J Med Chem. 2013 Aug;66:380-7. PMID: 23827178.
Dal Piaz F, Cotugno R, Lepore L, et al. Chemical proteomics reveals HSP70 1A as a target for the anticancer diterpene oridonin in Jurkat cells. J Proteomics. 2013 Apr 26;82:14-26. PMID: 23416714.
Yin B, Sheng H, Lin J, et al. The cell death of C6 astrocytoma cells induced by oridonin and its mechanism. Int J Clin Exp Pathol. 2012;5(6):562-8. PMID: 22949939.
Li X, Li X, Wang J, et al. Oridonin up-regulates expression of P21 and induces autophagy and apoptosis in human prostate cancer cells. Int J Biol Sci. 2012;8(6):901-12. PMID: 22745580.
