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Ceftriaxone Disodium Hemiheptahydrate

Ceftriaxone Disodium Hemiheptahydrate

Product ID C1637
Cas No. 104376-79-6
Purity ≥98%
Product Unit SizeCostQuantityStock
250 mg $49.70 In stock
500 mg $82.70 In stock
1 g $148.90 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
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  • References
  • Description
  • Product Info
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Description

Ceftriaxone is a third generation β-lactam cephalosporin antibiotic. Ceftriaxone exhibits antibacterial efficacy against gram positive and gram negative bacteria, inhibiting penicillin binding protein activity to prevent peptidoglycan synthesis and bacterial cell wall formation. Ceftriaxone is also neuroprotective. This compound displays cognition enhancing benefit, suppressing traumatic brain injury-induced brain edema and cognitive function deficits in animal models by decreasing autophagy and upregulating expression of glutamate transporter GLT-1; this also results in protection in animal models of Huntington’s disease and attenuates the development of dependence and abstinence-induced withdrawal in animal models of substance abuse.

Product Info

Cas No.

104376-79-6

Purity

≥98%

Formula

C18H16N8O7S3Na2 • 7/2H2O

Formula Wt.

661.60

Chemical Name

(6R,7R)-7-[[(2Z)-(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)-thio]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Disodium Salt Hemiheptahydrate

IUPAC Name

disodium;(6R,7R)-7-[[(2Z)-2-(2-amino-1, 3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(2-methyl-6-oxido-5-oxo-1,2,4-triazin-3-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;hydrate

Synonym

Ceftriaxone disodium slat hemiheptahydrate, Rocefin, Rocephine

Melting Point

>155°C (dec.)

Solubility

Soluble in water (40 g/100 ml). DMSO 1 mg/mL.

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

C1637 MSDS PDF

Info Sheet

C1637 Info Sheet PDF

References

Cui C, Cui Y, Gao J, et al. Neuroprotective effect of ceftriaxone in a rat model of traumatic brain injury. Neurol Sci. 2014 May;35(5):695-700. PMID: 24277205.

Sari Y, Prieto AL, Barton SJ, et al. Ceftriaxone-induced up-regulation of cortical and striatal GLT1 in the R6/2 model of Huntington's disease. J Biomed Sci. 2010 Jul 27;17:62. PMID: 20663216.

Rawls SM, Cavallo F, Capasso A, et al. The beta-lactam antibiotic ceftriaxone inhibits physical dependence and abstinence-induced withdrawal from cocaine, amphetamine, methamphetamine, and clorazepate in planarians. Eur J Pharmacol. 2008 Apr 28;584(2-3):278-84. PMID: 18342307.

Barriere SL, Flaherty JF. Third-generation cephalosporins: a critical evaluation. Clin Pharm. 1984 Jul-Aug;3(4):351-73. PMID: 6432420.

Custom Order

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