LKT Labs

Biochemicals for Life Science Research

Dexamethasone Phosphate Sodium

Product ID D1695
Cas No. 2392-39-4
Purity ≥98%
Product Unit SizeCostQuantityStock
100 mg $68.00 In stock
500 mg $212.40 In stock
1 g $356.80 In stock
Bulk Quote

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Description

Dexamethasone is a glucocorticoid that exhibits anti-inflammatory and immunosuppressive activities with minimal mineralocorticoid effect. Under inflammatory conditions, dexamethasone decreases secretion of TNF, IL-6, and IL-1β, inhibiting migration and maturation of macrophages. Dexamethasone may also display anti-asthma benefit as well, through the upregulation of PTEN expression. Additionally, dexamethasone is often used in combination with other chemotherapeutics in the treatment of multiple myeloma.

Product Info

Cas No.

2392-39-4
Purity

≥98%
Formula

C22H28FO8PNa2
Formula Wt.

516.40
Chemical Name

(11β, 16α)-9-Fluoro-11,17,21-trihydroxy-16- methylpregna-1,4-diene-3,20-dione 21-phosphate disodium salt
IUPAC Name

disodium;[2-[(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11, 17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15, 16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] phosphate
Synonym

Dexamethasone 21-Phosphate Disodium Salt, Ak-Dex, Baldex, Dalalone, Dezone, Hexadrol, Oradexon, Soldesam

Melting Point

238-239°C
Solubility

Soluble in water (500 mg/mL).

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

D1695 MSDS PDF
Info Sheet

D1695 Info Sheet PDF

References

Bartneck M, Peters FM, Warzecha KT, et al. Liposomal encapsulation of dexamethasone modulates cytotoxicity, inflammatory cytokine response, and migratory properties of primary human macrophages. Nanomedicine. 2014 Mar 7. [Epub ahead of print]. PMID: 24607939.

Ni Z, Tang J, Cai Z, et al. A new pathway of glucocorticoid action for asthma treatment through the regulation of PTEN expression. Respir Res. 2011 Apr 14;12:47. PMID: 21489309.

Morgan G. Future drug developments in multiple myeloma: an overview of novel lenalidomide-based combination therapies. Blood Rev. 2010 Nov;24 Suppl 1:S27-32. PMID: 21126634.

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