Dexamethasone Phosphate Sodium

Name: Dexamethasone Phosphate Sodium
SKU: D1695
Availability: InStock

Product ID D1695

Cas No. 2392-39-4

Purity ≥98%

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Product Info
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Description

Dexamethasone is a glucocorticoid that exhibits anti-inflammatory and immunosuppressive activities with minimal mineralocorticoid effect. Under inflammatory conditions, dexamethasone decreases secretion of TNF, IL-6, and IL-1β, inhibiting migration and maturation of macrophages. Dexamethasone may also display anti-asthma benefit as well, through the upregulation of PTEN expression. Additionally, dexamethasone is often used in combination with other chemotherapeutics in the treatment of multiple myeloma.

Product Info

Cas No.	2392-39-4
Purity	≥98%
Formula	C₂₂H₂₈FO₈PNa₂
Formula Wt.	516.40
Chemical Name	(11β, 16α)-9-Fluoro-11,17,21-trihydroxy-16- methylpregna-1,4-diene-3,20-dione 21-phosphate disodium salt
IUPAC Name	disodium;[2-[(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11, 17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15, 16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] phosphate
Synonym	Dexamethasone 21-Phosphate Disodium Salt, Ak-Dex, Baldex, Dalalone, Dezone, Hexadrol, Oradexon, Soldesam
Melting Point	238-239°C
Solubility	Soluble in water (500 mg/mL).
Appearance	White Crystal Powder

Shipping and Storage

Store Temp	4°C
Ship Temp	Ambient

Downloads

MSDS	D1695 MSDS PDF
Info Sheet	D1695 Info Sheet PDF

References

Bartneck M, Peters FM, Warzecha KT, et al. Liposomal encapsulation of dexamethasone modulates cytotoxicity, inflammatory cytokine response, and migratory properties of primary human macrophages. Nanomedicine. 2014 Mar 7. [Epub ahead of print]. PMID: 24607939.

Ni Z, Tang J, Cai Z, et al. A new pathway of glucocorticoid action for asthma treatment through the regulation of PTEN expression. Respir Res. 2011 Apr 14;12:47. PMID: 21489309.

Morgan G. Future drug developments in multiple myeloma: an overview of novel lenalidomide-based combination therapies. Blood Rev. 2010 Nov;24 Suppl 1:S27-32. PMID: 21126634.