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AT-7519 Hydrochloride

AT-7519 Hydrochloride

Product ID A761003
Cas No. 902135-91-5
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $99.80 In stock
25 mg $341.30 In stock
100 mg $682.50 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

AT-7519 is an ATP competitive CDK inhibitor showing activity against CDK1, 2, 4, 6, and 9. It causes cell cycle arrest followed by apoptosis in human tumor cells and inhibits tumor growth in human tumor xenograft models. It also induces apoptosis in multiple myeloma cells via GSK-3β activation.

Product Info

Cas No.

902135-91-5

Purity

≥98%

Formula

C16H17Cl2N5O2 • HCl

Formula Wt.

418.70

Chemical Name

n-(4-Piperidinyl)-4-(2,6-dichlorobenzoylamino)-1h-pyrazole-3-carboxamide hydrochloride

IUPAC Name

4-[(2,6-Dichlorobenzoyl)amino]-N-(4-piperidinyl)-1H-pyrazole-3-carboxamide hydrochloride (1:1)

Synonym

AT 7519 HCl; 4-(2,6-dichlorobenzamido)-N-(piperidin-4-yl)-1H-pyrazole-3-carboxamide hydrochloride

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

A761003 MSDS PDF

Info Sheet

A761003 Info Sheet PDF

References

Santo L., Vallet S., et al. AT7519, A novel small molecule multi-cyclin-dependent kinase inhibitor, induces apoptosis in multiple myeloma via GSK-3β activation and RNA polymerase II inhibition. Oncogene. 29:2325-2336 (2010). PMID: 20101221.

Squires M., Feltell R., et al. Biological characterization of AT7519, a small-molecule inhibitor of cyclin-dependent kinases, in human tumor cell lines. Molecular Cancer Therapeutics. 8(2):324-332 (2009). PMID: 19174555.

Custom Order

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