LKT Labs

Biochemicals for Life Science Research

Protopanaxatriol

Product ID P6958
Cas No. 34080-08-5
Purity ≥95%
Product Unit SizeCostQuantityStock
1 mg $103.60 In stock
5 mg $231.50 In stock
10 mg $388.90 In stock
25 mg $759.30 In stock
Bulk Quote

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Description

Protopanaxatriol is a triterpene sapogenin originally found in species of Panax (ginseng) that exhibits antihypertensive, neuromodulatory, and antioxidative activities. Protopanaxatriol prevents breakdown of vitamin D3 and inhibits GABA-A and GABA-C receptors as well as slow-activating delayed rectifier K+ channels. Protopanaxatriol also stimulates production of eNOS and NO, increasing vascular relaxation and decreasing blood pressure. In animal models of isoproterenol-induced myocardial injury, protopanaxatriol decreases levels of maldionaldehyde and increases activity of superoxide dismutase and glutathione peroxidase.

Product Info

Cas No.

34080-08-5
Purity

≥95%
Formula

C30H52O4
Formula Wt.

476.73
IUPAC Name

(3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-17-[(2R)-2-hydroxy-6-methylhept-5-en-2-yl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,6,12-triol
Appearance

White to off white powder

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

P6958 MSDS PDF
Info Sheet

P6958 Info Sheet PDF

References

Deb S, Chin MY, Adomat H, et al. Ginsenoside-mediated blockade of 1α,25-dihydroxyvitamin D3 inactivation in human liver and intestine in vitro. J Steroid Biochem Mol Biol. 2014 May;141:94-103. PMID: 24486455.

Lee BH, Hwang SH, Choi SH, et al. Inhibitory Effects of Ginsenoside Metabolites, Compound K and Protopanaxatriol, on GABAC Receptor-Mediated Ion Currents. Korean J Physiol Pharmacol. 2013 Apr;17(2):127-32. PMID: 23626474.

Hong SY, Kim JY, Ahn HY, et al. Panax ginseng extract rich in ginsenoside protopanaxatriol attenuates blood pressure elevation in spontaneously hypertensive rats by affecting the Akt-dependent phosphorylation of endothelial nitric oxide synthase. J Agric Food Chem. 2012 Mar 28;60(12):3086-91. PMID: 22380784.

Lee BH, Choi SH, Shin TJ, et al. Effects of Ginsenoside Metabolites on GABAA Receptor-Mediated Ion Currents. J Ginseng Res. 2012 Jan;36(1):55-60. PMID: 23717104

Han B, Meng Q, Li Q, et al. Effect of 20(S)-protopanaxatriol and its epimeric derivatives on myocardial injury induced by isoproterenol. Arzneimittelforschung. 2011;61(3):148-52. PMID: 21528638.

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