LKT Labs

Biochemicals for Life Science Research

Gastrin I, human

Product ID G0180
Cas No. 10047-33-3
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $281.90 In stock
2 mg $478.40 In stock
5 mg $845.60 Please Inquire
Bulk Quote

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Description

Gastrin I, like gastrin, acts as an agonist at the cholestocystokinin 2 (CCK2) receptor, exhibiting anorexigenic and gastrointestinal motility modulating activities. Gastrin is an endogenous peptide that inhibits food intake and slows gastric emptying, constricting the pyloric sphincter in vivo. Additionally, gastrin increases release of histamine and induces membrane translocation of the H+/K+ ATPase, stimulating gastric acid release. Expression of this particular fragment of gastrin (18-34) may correlate with the occurrence of tumor tissues in some cancers.

Product Info

Cas No.

10047-33-3
Purity

≥98%
Formula

C130H204N38O31S
Formula Wt.

2098.22
Synonym

18-Pyroglutamic acid, big gastrin I-(18-34)-peptide amide, human, [pGlu18]-Big gastrin I fragment 18-34 amide, Gastrin I, heptadecapeptide, HG-17, Little gastrin I, Little gastrin
Solubility

Soluble in 1% Ammonia (1 mg/mL).

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

G0180 MSDS PDF
Info Sheet

G0180 Info Sheet PDF

References

Furuse M, Ao R, Bungo T, et al. Central gastrin inhibits feeding behavior and food passage in neonatal chicks. Life Sci. 1999;65(3):305-11. PMID: 10447216.

Zimmerhackl B, Wünsch E, Classen M, et al. In man histamine and muscarinergic mechanisms are essential mediators of acid secretion in response to synthetic human gastrin (1-17). Regul Pept. 1993 Jul 23;46(3):583-92. PMID: 8105512.

Rattan S, Coln D, Goyal RK. The mechanism of action of gastrin on the lower esophageal sphincter. Gastroenterology. 1976 May;70(5 PT.1):828-31. PMID: 1261781.

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