Name: GSK-2334470
SKU: G7344
Availability: InStock

Description

GSK-2334470 is a selective inhibitor of PDK1 that exhibits anticancer activity in in vitro models. GSK-2334470 inhibits T-loop phosphorylation of SGK and S6K1, Akt and Akt substrates GSK3, FoxO, and PRAS40, and ERK substrate RSK2.

Product Info

Cas No.	1227911-45-6
Purity	≥99%, ≥99%ee
Formula	C₂₅H₃₄N₈O
Formula Wt.	462.59
Chemical Name	(3S,6R)-1-[6-(3-amino-1H-indazol-6-yl)-2-(methylamino)pyrimidin-4-yl]-N-cyclohexyl-6-methylpiperidine-3-carboxamide
IUPAC Name	(3S,6R)-1-[6-(3-amino-1H-indazol-6-yl)-2-(methylamino)pyrimidin-4-yl]-N- cyclohexyl-6-methylpiperidine-3-carboxamide
Solubility	DMSO 28 mg/mL (64.6 mM) Water Insoluble Ethanol Insoluble
Appearance	off-white powder

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	G7344 MSDS PDF
Info Sheet	G7344 Info Sheet PDF

References

Najafov A, Sommer EM, Axten JM, et al. Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1. Biochem J. 2011 Jan 15;433(2):357-69. PMID: 21087210.

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GSK-2334470

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