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Mirtazapine

Product ID M3368
Cas No. 61337-67-5
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $92.30 In stock
50 mg $369.40 In stock
250 mg $1,199.80 In stock
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  • Description
  • Product Info
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  • References
  • Description
  • Product Info
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  • Downloads
  • References
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Description

Mirtazapine is a piperazine antidepressant that also displays anxiolytic, hypnotic, antiemetic, and orexigenic activity. Mirtazapine acts as an antagonist at 5-HT2/3 receptors, an indirect agonist at 5-HT1 receptors, and an antagonist at α2-adrenergic receptors, enhancing NE and 5-HT neurotransmission. The sleep-inducing hypnotic effects are mediated through mirtazapine’s inverse agonism at histamine H1 receptors, although tolerance to this effect develops during chronic use. Clinically, mirtazapine improves the withdrawal symptom profile and aids in preventing relapse in recently abstinent substance abusers in a manner similarly to other antidepressants. This compound also shows efficacy in treating behavioral complications associated with autism spectrum disorder and pervasive developmental disorder.

Product Info

Cas No.

61337-67-5

Purity

≥98%

Formula

C17H19N3

Formula Wt.

265.35

Chemical Name

Pyrazino(2,1-a)pyrido(2,3-c)(2)benzazepine, 1,2,3,4,10,14b-hexahydro-2-methyl-

IUPAC Name

CN1CCN2C(C1)C3=CC=CC=C3CC4=C2N=CC=C4

Synonym

Remeron

Melting Point

104-108°C

Solubility

Soluble in DMSO (~8mg/mL).

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

M3368 MSDS PDF

Info Sheet

M3368 Info Sheet PDF

References

Kongsakon R, Papadopoulos KI, Saguansiritham R. Mirtazapine in amphetamine detoxification: a placebo-controlled pilot study. Int Clin Psychopharmacol. 2005 Sep;20(5):253-6. PMID: 16096515.

Liappas J, Paparrigopoulos T, Malitas P, et al. Mirtazapine improves alcohol detoxification. J Psychopharmacol. 2004 Mar;18(1):88-93. PMID: 15107190.

Nutt DJ. Tolerability and safety aspects of mirtazapine. Hum Psychopharmacol. 2002 Jun;17 Suppl 1:S37-41. PMID: 12404669.

Posey DJ, Guenin KD, Kohn AE, et al. A naturalistic open-label study of mirtazapine in autistic and other pervasive developmental disorders. J Child Adolesc Psychopharmacol. 2001 Fall;11(3):267-77. PMID: 11642476.

Anttila SA, Leinonen EV. A review of the pharmacological and clinical profile of mirtazapine. CNS Drug Rev. 2001 Fall;7(3):249-64. PMID: 11607047.

de Boer TH, Maura G, Raiteri M, et al. Neurochemical and autonomic pharmacological profiles of the 6-aza-analogue of mianserin, Org 3770 and its enantiomers. Neuropharmacology. 1988 Apr;27(4):399-408. PMID: 3419539.

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