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Hydroxyzine is a first generation antihistamine that acts as an inverse agonist at histamine H1 receptors. Hydroxyzine exhibits anti-allergic, antipsychotic, anxiolytic, and sedative activities; it is the parent compound of cetirizine. Hydroxyzine also inhibits 5-HT2A, D1/2, and α1-adrenergic receptors and acts as a functional inhibitor of acid sphingomyelinase (FIASMA).
| Cas No. | 2192-20-3 |
|---|---|
| Purity | ≥98% |
| Formula | C21H27ClN2O2 • 2HCl |
| Formula Wt. | 447.83 |
| Chemical Name | Ethanol, 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1- piperazinyl)ethoxy)-, dihydrochloride |
| IUPAC Name | 2-[2-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]ethanol; dihydrochloride |
| Synonym | Alamon, Atarax, Aterax, Durrax, Orgatrax, Quiess, Vistaril Parental. |
| Melting Point | 193°C |
| Solubility | Soluble in water (<700mg/mL), ethanol (220 mg/mL), chloroform (60mg/mL) or acetone (2mg/mL). |
| Appearance | White of almost white powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Llorca PM, Spadone C, Sol O, et al. Efficacy and safety of hydroxyzine in the treatment of generalized anxiety disorder: a 3-month double-blind study. J Clin Psychiatry. 2002 Nov;63(11):1020-7. PMID: 12444816.
Minogiannis P, El-Mansoury M, Betances JA, et al. Hydroxyzine inhibits neurogenic bladder mast cell activation. Int J Immunopharmacol. 1998 Oct;20(10):553-63. PMID: 9839659.
Haraguchi K, Ito K, Kotaki H, et al. Prediction of drug-induced catalepsy based on dopamine D1, D2, and muscarinic acetylcholine receptor occupancies. Drug Metab Dispos. 1997 Jun;25(6):675-84. PMID: 9193868.
Snowman AM, Snyder SH. Cetirizine: actions on neurotransmitter receptors. J Allergy Clin Immunol. 1990 Dec;86(6 Pt 2):1025-8. PMID: 1979798.
