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GDC-0994

Product ID G124080
Cas No. 1453848-26-4
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $92.80 In stock
5 mg $244.70 In stock
25 mg $673.70 In stock
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  • Product Info
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  • Description
  • Product Info
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Description

GDC-0994 is an inhibitor of ERK1/2, which is commonly activated by oncogenic mutations in B-Raf or Ras. It is effective against cancer cell lines that are resistant to B-Raf and MEK1/2 inhibitor therapy. Combination therapy targeting multiple nodes of the Ras/Raf/MEK/ERK signaling cascade enhances efficacy and diminishes the potential for acquired drug resistance.

Product Info

Cas No.

1453848-26-4

Purity

≥98%

Formula

C21H18ClFN6O2

Formula Wt.

440.86

IUPAC Name

1-[(1S)-1-(4-chloro-3-fluorophenyl)-2-hydroxyethyl]-4-[2-[(2-methylpyrazol-3-yl)amino]pyrimidin-4-yl]pyridin-2-one

Synonym

GDC0994; RG7842; Ravoxertinib

Solubility

Ethanol (30 mg/mL), DMSO (30 mg/mL), DMF (30 mg/mL).

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

G124080 MSDS PDF

Info Sheet

G124080 Info Sheet PDF

References

Roskoski R. Targeting ERK1/2 protein-serine/threonine kinases in human cancers. Pharmacol Res. 142:151-168 (2019). PMID: 30794926.

Blake J., Burkard M., et al. Discovery of (S)-1-(1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one (GDC-0994), an Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibitor in Early Clinical Development. J Med Chem. 59(12):5650-60 (2016). PMID: 27227380.

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