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Eplerenone

Eplerenone

Product ID E6245
Cas No. 107724-20-9
Purity ≥99%
Product Unit SizeCostQuantityStock
10 mg $142.90 In stock
25 mg $306.20 In stock
100 mg $918.80 In stock
Bulk Quote

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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
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  • Downloads
  • References
  • Custom Order

Description

Eplerenone displays antihypertensive, anti-inflammatory, and anti-angiogenic activities; it inhibits the mineralocorticoid receptor. Eplerenone inhibits aldosterone-induced expression of COX (therefore decreasing PGE2 levels), preventing the induction of COX and resulting kidney damage in high salt diets. This compound also prevents salt-induced increases in NOX expression, decreasing oxidative stress in the kidney as well. In spontaneously hypertensive rats, eplerenone inhibited cardiac remodeling (hypertrophy) and left ventricle dysfunction. The antiangiogenic activity of eplerenone is characterized by its inhibition of VEGF expression in the kidney.

Product Info

Cas No.

107724-20-9

Purity

≥99%

Formula

C24H30O6

Formula Wt.

414.29

Chemical Name

methyl (1R,2S,9R,10R,11S,14R,15S,17R)-2,15-dimethyl-5,5'-dioxospiro[18-oxapentacyclo[8.8.0.01,17.02,7.011,15]octadec-6-ene-14,2'-oxolane]-9-carboxylate

IUPAC Name

methyl (1R,2S,9R,10R,11S,14R,15S,17R)-2,15-dimethyl-5,5'-dioxospiro[18-oxapentacyclo[8.8.0.01,17.02,7.011,15]octadec-6-ene-14,2'-oxolane]-9-carboxylate

Synonym

Epoxymexrenone, Inspra, Selara

Solubility

CH3CN

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

E6245 MSDS PDF

Info Sheet

E6245 Info Sheet PDF

References

Yasuoka S, Kai H, Kajimoto H, et al. Blood pressure variability activates cardiac mineralocorticoid receptor and induces cardiac remodeling in hypertensive rats. Circ J. 2013;77(6):1474-81. PMID: 23470864.

Bayorh M, Rollins-Hairston A, Adiyiah J, et al. Eplerenone inhibits aldosterone-induced renal expression of cyclooxygenase. J Renin Angiotensin Aldosterone Syst. 2012 Sep;13(3):353-9. PMID: 22554826.

Bayorh MA, Rollins-Hairston A, Adiyiah J, et al. Eplerenone suppresses aldosterone/ salt-induced expression of NOX-4. J Renin Angiotensin Aldosterone Syst. 2011 Sep;12(3):195-201. PMID: 21292834.

Eatman D, Layas MF, Bayorh MA. Eplerenone Suppresses Salt-Induced Vascular Endothelial Growth Factor Expression in the Kidney. Kidney Blood Press Res. 2010 Jun 23;33(3):167-173. PMID: 20571278.

Custom Order

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