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Anacetrapib

Product ID A5301
Cas No. 875446-37-0
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $250.50 In stock
10 mg $457.80 In stock
25 mg $858.50 In stock
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  • Description
  • Product Info
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  • Description
  • Product Info
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  • Downloads
  • References
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Description

Anacetrapib is a cholesterol ester transfer protein (CETP) inhibitor that exhibits anti-atherosclerotic activity. In vivo, anacetrapib inhibits the development of atherosclerosis and decreases levels of VLDL and PCSK9. In a clinical setting, this compound decreases levels of LDL and ApoB. Additionally, anacetrapib may increase levels of HDL and ApoA1.

Product Info

Cas No.

875446-37-0

Purity

≥98%

Formula

C30H25F10NO3

Formula Wt.

637.52

Chemical Name

(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-[[2-(4-fluoro-2-methoxy-5-propan-2-ylphenyl)-5-(trifluoromethyl)phenyl]methyl]-4-methyl-1,3-oxazolidin-2-one

IUPAC Name

(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-[[2-(4-fluoro-2-methoxy-5-propan-2-ylphenyl)-5-(trifluoromethyl)phenyl]methyl]-4-methyl-1,3-oxazolidin-2-one

Synonym

MK-0859

Solubility

DMSO 200mM Ethanol 200mM Water Insoluble

Appearance

White powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

A5301 MSDS PDF

Info Sheet

A5301 Info Sheet PDF

References

van der Tuin SJ, Kühnast S, Berbée JF, et al. Anacetrapib reduces (V)LDL cholesterol by inhibition of CETP activity and reduction of plasma PCSK9. J Lipid Res. 2015 Nov;56(11):2085-93. PMID: 26342106.

Millar JS, Reyes-Soffer G, Jumes P, et al. Anacetrapib lowers LDL by increasing ApoB clearance in mildly hypercholesterolemic subjects. J Clin Invest. 2015 Jun;125(6):2510-22. PMID: 25961461.

Äijänen T, Koivuniemi A, Javanainen M, et al. How anacetrapib inhibits the activity of the cholesteryl ester transfer protein? Perspective through atomistic simulations. PLoS Comput Biol. 2014 Nov 20;10(11):e1003987. PMID: 25412509.

Hooper AJ, Burnett JR. Anacetrapib, a cholesteryl ester transfer protein inhibitor. Expert Opin Investig Drugs. 2012 Jan;21(1):103-9. PMID: 22191425.

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