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CCT-128930

Product ID C1176
Cas No. 885499-61-6
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $92.80 In stock
5 mg $197.60 In stock
10 mg $361.10 In stock
25 mg $661.00 In stock
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Description

CCT-128930 is a pyrrolopyrimidine that inhibits Akt and exhibits anticancer chemotherapeutic activity. In hepatoma cancer cells, this compound induces G1 phase cell cycle arrest, apoptosis, and autophagy, upregulates expression of p21, p27, and p53, and suppresses cell proliferation. CCT-128930 also induces G1 phase cell cycle arrest in glioblastoma cells and limits tumor growth in animal models with breast cancer xenografts.

Product Info

Cas No.

885499-61-6

Purity

≥98%

Formula

C18H20ClN5

Formula Wt.

341.84

Chemical Name

4-(4-Chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinamine

IUPAC Name

4-(4-Chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinamine

Synonym

CCT128930

Solubility

DMSO 68 mg/mL Ethanol 6 mg/mL Water Insoluble

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

C1176 MSDS PDF

Info Sheet

C1176 Info Sheet PDF

References

Wang FZ, Chang ZY, Fei HR, et al. CCT128930 induces cell cycle arrest, DNA damage, and autophagy independent of Akt inhibition. Biochimie. 2014 Aug;103:118-25. PMID: 24793486.

Yap TA, Walton MI, Hunter LJ, et al. Preclinical pharmacology, antitumor activity, and development of pharmacodynamic markers for the novel, potent AKT inhibitor CCT128930. Mol Cancer Ther. 2011 Feb;10(2):360-71. PMID: 21191045.

Caldwell JJ, Davies TG, Donald A, et al. Identification of 4-(4-aminopiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidines as selective inhibitors of protein kinase B through fragment elaboration. J Med Chem. 2008 Apr 10;51(7):2147-57. PMID: 18345609.

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