LKT Labs

Biochemicals for Life Science Research

Brefeldin A

Product ID B6816
Cas No. 20350-15-6
Purity ≥97%
Product Unit SizeCostQuantityStock
5 mg $83.40 In stock
10 mg $138.90 In stock
Bulk Quote

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Description

Brefeldin A is a lactone antibiotic found in fungi such as Eupenicillium; it exhibits anticancer and antiviral activities. Brefeldin A inhibits activity of guanine nucleotide exchange factors, preventing association with COPI and COPI-mediated vesicle formation and suppressing protein transport from the endoplasmic reticulum to the Golgi apparatus. Brefeldin A is used in research models to study endoplasmic reticulum stress and protein transport. In vitro, this compound inhibits poliovirus replication. In prostate cancer cells, brefeldin A inhibits cell growth, induces apoptosis and G1 phase cell cycle arrest, decreases levels of p53, CDK2, CDK4, and cyclin D1, and causes cell death.

Product Info

Cas No.

20350-15-6
Purity

≥97%
Formula

C16H24O4
Formula Wt.

280.36
Chemical Name

1,6,7,8,9,11a,12,13,14,14a-Decahydro-1,13-dihydroxy- 6-methyl-4H-cyclopent[f]oxacyclotridecin-4-one
IUPAC Name

(1S,2E,7S,10E,12R,13R,15S)-12, 15-dihydroxy-7-methyl-8-oxabicyclo[11.3.0]hexadeca-2,10-dien-9-one
Synonym

Ascotoxin, Cyanein, Decumbin
Melting Point

204-205°C
Solubility

Soluble in methanol.

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

B6816 MSDS PDF
Info Sheet

B6816 Info Sheet PDF

References

Zhou C, Li C, Li D, et al. BIG1, a brefeldin A-inhibited guanine nucleotide-exchange protein regulates neurite development via PI3K-AKT and ERK signaling pathways. Neuroscience. 2013 Dec 19;254:361-8. PMID: 24090963.

Rouhana J, Padilla A, Estaran S, et al. Kinetics of interaction between ADP-ribosylation factor-1 (Arf1) and the Sec7 domain of Arno guanine nucleotide exchange factor, modulation by allosteric factors, and the uncompetitive inhibitor brefeldin A. J Biol Chem. 2013 Feb 15;288(7):4659-72. PMID: 23255605.

Chapman JR, Tazaki H, Mallouh C, et al. Brefeldin A-induced apoptosis in prostatic cancer DU-145 cells: a possible p53-independent death pathway. BJU Int. 1999 Apr;83(6):703-8. PMID: 10233583.

Cuconati A, Molla A, Wimmer E. Brefeldin A inhibits cell-free, de novo synthesis of poliovirus. J Virol. 1998 Aug;72(8):6456-64. PMID: 9658088.

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