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Altretamine

Product ID A4578
Cas No. 645-05-6
Purity ≥98%
Product Unit SizeCostQuantityStock
100 mg $83.40 In stock
500 mg $111.30 In stock
1 g $185.30 In stock
5 g $555.70 In stock
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  • Product Info
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  • Description
  • Product Info
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  • Downloads
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Description

Altretamine is an anticancer chemotherapeutic agent that binds DNA at guanine and cytosine residues, forming DNA adducts. This alkylating agent is also metabolized to formaldehyde. Altretamine is clinically used to treat ovarian cancer.

Product Info

Cas No.

645-05-6

Purity

≥98%

Formula

C9H18N6

Formula Wt.

210.28

Chemical Name

N,N,N',N',N'',N''-Hexamethyl-1,3,5-triazine-2,4,6-triamine

IUPAC Name

2-N,2-N,4-N,4-N,6-N,6-N-hexamethyl-1,3,5-triazine-2,4,6-triamine

Synonym

HMM, Hexalen, Hexamethylmelamine

Melting Point

172-174°C

Solubility

Practically insoluble in water. Soluble in DMSO.

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

A4578 MSDS PDF

Info Sheet

A4578 Info Sheet PDF

References

Chan JK, Loizzi V, Manetta A, et al. Oral altretamine used as salvage therapy in recurrent ovarian cancer. Gynecol Oncol. 2004 Jan;92(1):368-71. PMID: 14751188.

Coley HM, Brooks N, Phillips DH, et al. The role of the N-(hydroxymethyl)melamines as antitumour agents: mechanism of action studies. Biochem Pharmacol. 1995 May 11;49(9):1203-12. PMID: 7763301.

Hansen LA, Hughes TE. Altretamine. DICP. 1991 Feb;25(2):146-52. PMID: 1905441.

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