Biochemicals for Life Science Research
Altretamine is an anticancer chemotherapeutic agent that binds DNA at guanine and cytosine residues, forming DNA adducts. This alkylating agent is also metabolized to formaldehyde. Altretamine is clinically used to treat ovarian cancer.
HMM, Hexalen, Hexamethylmelamine
Practically insoluble in water. Soluble in DMSO.
White Crystal Powder
A4578 MSDS PDF
A4578 Info Sheet PDF
Chan JK, Loizzi V, Manetta A, et al. Oral altretamine used as salvage therapy in recurrent ovarian cancer. Gynecol Oncol. 2004 Jan;92(1):368-71. PMID: 14751188.
Coley HM, Brooks N, Phillips DH, et al. The role of the N-(hydroxymethyl)melamines as antitumour agents: mechanism of action studies. Biochem Pharmacol. 1995 May 11;49(9):1203-12. PMID: 7763301.
Hansen LA, Hughes TE. Altretamine. DICP. 1991 Feb;25(2):146-52. PMID: 1905441.