• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Bupivacaine Hydrochloride Monohydrate

Bupivacaine Hydrochloride Monohydrate

Product ID B8262
Cas No. 73360-54-0
Purity ≥98%
Product Unit SizeCostQuantityStock
1 g $69.70 In stock
5 g $204.30 In stock
25 g $714.70 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Bupivacaine is an amino amide anesthetic that decreases current amplitude and inhibits whole cell K+ currents in Ca2+-activated K+ channels and N-type voltage-gated (Kv1/Shaker and Kv3/Shaw [KCNA and KCNC]) K+ channels. Bupivacaine also inhibits voltage-gated Na+ channels and tandem pore domain (TASK-2/KCNK-5) K+ channels. Bupivacaine may be neurotoxic at high doses, activating p38 MAPK, increasing levels of ROS and WDR53, and inducing apoptosis in neuroblastoma cells. In other cellular models, bupivacaine induces depolarization of the mitochondrial membrane potential, resulting in apoptosis.

Product Info

Cas No.

73360-54-0

Purity

≥98%

Formula

C18H28N2O • HCl • H2O

Formula Wt.

342.91

Chemical Name

1-Butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide hydrochloride hydrate

IUPAC Name

1-butyl-N-(2, 6-dimethylphenyl)piperidine-2-carboxamide;hydrate;hydrochloride

Synonym

Bupivacaine hydrochloride monohydrate, Carbostesin, Marcaine, Sensorcaine

Melting Point

258.5°C

Solubility

Soluble in water. Slightly soluble in acetone, chloroform and ether.

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

B8262 MSDS PDF

Info Sheet

B8262 Info Sheet PDF

References

Harato M, Huang L, Kondo F, et al. Bupivacaine-induced apoptosis independently of WDR35 expression in mouse neuroblastoma Neuro2a cells. BMC Neurosci. 2012 Dec 10;13:149. PMID: 23227925.

Martín P, Enrique N, Palomo AR, et al. Bupivacaine inhibits large conductance, voltage- and Ca2+- activated K+ channels in human umbilical artery smooth muscle cells. Channels (Austin). 2012 May-Jun;6(3):174-80. PMID: 22688134.

Lu J, Xu SY, Zhang QG, et al. Bupivacaine induces apoptosis via mitochondria and p38 MAPK dependent pathways. Eur J Pharmacol. 2011 Apr 25;657(1-3):51-8. PMID: 21315711.

Cela O, Piccoli C, Scrima R, et al. Bupivacaine uncouples the mitochondrial oxidative phosphorylation, inhibits respiratory chain complexes I and III and enhances ROS production: results of a study on cell cultures. Mitochondrion. 2010 Aug;10(5):487-96. PMID: 20546950.

Nilsson J, Madeja M, Elinder F, et al. Bupivacaine blocks N-type inactivating Kv channels in the open state: no allosteric effect on inactivation kinetics. Biophys J. 2008 Dec;95(11):5138-52. PMID: 18790854.

Kindler CH, Paul M, Zou H, et al. Amide local anesthetics potently inhibit the human tandem pore domain background K+ channel TASK-2 (KCNK5). J Pharmacol Exp Ther. 2003 Jul;306(1):84-92. PMID: 12660311.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • Z1216

    Z-DEVD-AMC

    Caspase substrate.
    ≥95%
  • T3038

    Thienylnonanyl Isothiocyanate

    Thienylbutyl ITC analog.

    ≥98%
  • T0102

    7-epi-Taxol

    Taxane found in Taxus; potential microtubule de...

    ≥95%
  • G124082

    GDC-0941

    pan-PI3K inhibitor.

    ≥98%
  • T3305

    Tibolone

    Synthetic steroid hormone used in HRT; SERM, PR...

    ≥98%
  • H1794

    Hexamethonium Bromide Hydrate

    Non-depolarizing NMJ blocker; nAChR antagonist....

    ≥98%
  • B165121

    Bedaquiline Fumarate

    Bactericidal

    ≥98%
  • I7447

    1-Isothiocyanato-6-(methylsulfenyl)-hexane

    Synthetic ITC, erucin analog.

    ≥98%
  • A5133

    Amiloride Hydrochloride Dihydrate

    K+-sparing diuretic; ENaC and acid-sensing ion ...

    ≥98%
  • N1989

    Neurotensin

    Endogenous neuropeptide involved in hormone rel...

    ≥95%
  • M5753

    Monensin Sodium

    Polyether ionophore, autophagy inhibitor.

    ≥98%
  • S584778

    Sotorasib

    KRAS inhibitor

    ≥99%
  • W317520

    WIN 55,212-2 Mesylate

    Non-selective cannabinoid receptor agonist.

    ≥98%
  • A5057

    Amoxicillin

    β-lactam; penicillin binding protein inhibitor...

    ≥99%
  • A971336

    Azilsartan Medoxomil

    Prodrug

    ≥98%
  • T1655

    Tenoxicam Impurity 1

    Tenoxicam impurity

    ≥98%
  • E846182

    Everolimus EP Impurity E

    Impurity of everolimus

    ≥80%
  • K740640

    KSQ-4279

    USP1 inhibitor

    ≥98%
  • I7556

    1-Isothiocyanato-7-(methylsulfonyl)-heptane

    ITC, erysolin analog.

    ≥98%
  • C1868

    Cerebellin

    Peptide, involved in synapse formation and cell...

    ≥95%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only