• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
E64-d

E64-d

Product ID E0003
Cas No. 88321-09-9
Purity ≥97%
Product Unit SizeCostQuantityStock
1 mg $91.00 In stock
5 mg $364.60 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

E64d is an inhibitor of cathepsins that exhibits neuroprotective activity. In vivo, E64d inhibits cathepsin D, decreasing brain amyloid-β (Aβ) plaque formation. E64d inhibition of cathepsins also aggravates left ventricular dysfunction in animal models of myocardial infarction.

Product Info

Cas No.

88321-09-9

Purity

≥97%

Formula

C17H30N2O5

Formula Wt.

342.43

IUPAC Name

ethyl (2S,3S)-3-[[(2S)-4-methyl-1-(3-methylbutylamino)-1-oxopentan-2-yl]carbamoyl]oxirane-2-carboxylate

Synonym

Aloxistatin

Solubility

Soluble in ethanol (>10 mg/ml), DMSO (20 mg/ml), DMF (30 mg/ml), and 1:1 DMSO:PBS (pH 7.2) (~0.5 mg/ml). Insoluble in water.

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

E0003 MSDS PDF

Info Sheet

E0003 Info Sheet PDF

References

Hook G, Yu J, Toneff T, et al. Brain Pyroglutamate Amyloid-Beta is Produced by Cathepsin B and is Reduced by the Cysteine Protease Inhibitor E64d, Representing a Potential Alzheimer's Disease Therapeutic. J Alzheimers Dis. 2014 Mar 4. [Epub ahead of print]. PMID: 24595198.

Chen H, Wang J, Xiang MX, et al. Cathepsin S-mediated fibroblast trans-differentiation contributes to left ventricular remodelling after myocardial infarction. Cardiovasc Res. 2013 Oct 1;100(1):84-94. PMID: 23771947.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • P8118

    Puerarin

    Isoflavone daidzein derivative found in Puerari...

    ≥96%
  • K1677

    Ketoprofen

    NSAID; COX-1/2 and lactate dehydrogenase inhibi...

    ≥98%
  • S1061

    Small Cardioactive Peptide B

    Peptide found in molluscs, cardiomodulator.

    ≥95%
  • P3597

    Pizotyline Malate

    5-HT1A partial agonist, 5-HT2C antagonist.

    ≥98%
  • B8112

    Budesonide

    Steroid; glucocorticoid agonist.

    ≥97%
  • D3420

    4-(3,4-Difluorobenzo)curcumin

    Curcumin derivative.

    ≥95%
  • S7970

    Strontium Ranelate

    Bone deterioration inhibitor, potential CaR ago...

    ≥98%
  • N0068

    Naringenin

    Flavanone found in species of Citrus. Naringen...

    ≥98%
  • C4274

    CKS-17

    Synthetic peptide, retroviral envelope protein ...

    ≥95%
  • P3542

    PIK-93

    p110α and p110γ PI3K inhibitor.

    ≥98%
  • H9815

    25-Hydroxyvitamin D3

    Vitamin D, calcitriol prodrug; VDR agonist.

    ≥98%
  • O1178

    n-Octyl-3-methylcaffeate

    Derivative of methyl caffeate, hydroxycinnamic ...

    ≥98%
  • H9862

    Hypothemycin

    Polyketide found in Setophoma.

    ≥96%
  • G0175

    Gastric Inhibitory Peptide, human

    Endogenous peptide hormone, somatostatin analog...

    ≥95%
  • G0181

    Gastrin Releasing Peptide, human

    Endogenous bombesin-like peptide, involved in f...

    ≥95%
  • E6257

    Epothilone B

    Microtubule depolymerization inhibitor.

    ≥98%
  • B1668

    Berteroin

    Thio sulforaphane analog, ITC.

    ≥97%
  • M1770

    Meropenem Sodium Carbonate

    Carbapenem β-lactam; penicillin binding protei...

    ≥98%
  • W5727

    Wogonoside

    Flavonoid glycoside found in Scutellaria.

    ≥98%
  • A985136

    AZD5991

    Mcl-1 inhibitor

    ≥99%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only