Medroxyprogesterone 17-Acetate

Product ID M1613

Cas No. 71-58-9

Purity ≥98%

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Product Info
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Downloads
References

Description
Product Info
Shipping and Storage
Downloads
References
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Description

Medroxyprogesterone 17-acetate (MPA) is a synthetic steroid that activates progesterone, androgen, and glucocorticoid receptors. MPA exhibits contraceptive and anticancer activities and is also used in hormone replacement therapy, endometriosis, and dysmenorrhea. MPA decreases levels of adrenocorticotropic hormone (ACTH), cortisol, and other hormones; it also inhibits 3α-hydroxysteroid dehydrogenase. This compound is used clinically to treat breast cancer and inhibits the proliferation and growth of breast cancer cells and tumors in various models.

Product Info

Cas No.	71-58-9
Purity	≥98%
Formula	C₂₄H₃₄O₄
Formula Wt.	386.52
Chemical Name	17-α-Acetoxy-6α-methylprogesterone
IUPAC Name	[(6S,8R,9S,10R,13S,14S,17R)-17-acetyl-6,10,13-trimethyl-3-oxo-2,6,7,8,9, 11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate
Synonym	MAP, Clinovir, Depo-Provera, Farlutal, Nidaxin, Oragest, Prodasone, Provera, Veramix
Melting Point	207-209°C
Solubility	Soluble in chloroform or acetone.
Appearance	White to off white powder

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	M1613 MSDS PDF
Info Sheet	M1613 Info Sheet PDF

References

Schindler AE, Campagnoli C, Druckmann R, et al. Classification and pharmacology of progestins. Maturitas. 2008 Sep-Oct;61(1-2):171-80. PMID: 19434889.

Meyer L, Venard C, Schaeffer V, et al. The biological activity of 3alpha-hydroxysteroid oxido-reductase in the spinal cord regulates thermal and mechanical pain thresholds after sciatic nerve injury. Neurobiol Dis. 2008 Apr;30(1):30-41. PMID: 18291663.

Poulin R, Baker D, Poirier D, et al. Androgen and glucocorticoid receptor-mediated inhibition of cell proliferation by medroxyprogesterone acetate in ZR-75-1 human breast cancer cells. Breast Cancer Res Treat. 1989 Mar;13(2):161-72. PMID: 2525057.