LKT Labs

Biochemicals for Life Science Research

Medroxyprogesterone 17-Acetate

Product ID M1613
Cas No. 71-58-9
Purity ≥99%
Product Unit SizeCostQuantityStock
500 mg $70.60 In stock
1 g $117.70 In stock
5 g $452.20 In stock
Bulk Quote

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Description

Medroxyprogesterone 17-acetate (MPA) is a synthetic steroid that activates progesterone, androgen, and glucocorticoid receptors. MPA exhibits contraceptive and anticancer activities and is also used in hormone replacement therapy, endometriosis, and dysmenorrhea. MPA decreases levels of adrenocorticotropic hormone (ACTH), cortisol, and other hormones; it also inhibits 3α-hydroxysteroid dehydrogenase. This compound is used clinically to treat breast cancer and inhibits the proliferation and growth of breast cancer cells and tumors in various models.

Product Info

Cas No.

71-58-9
Purity

≥99%
Formula

C24H34O4
Formula Wt.

386.52
Chemical Name

17-α-Acetoxy-6α-methylprogesterone
IUPAC Name

[(6S,8R,9S,10R,13S,14S,17R)-17-acetyl-6,10,13-trimethyl-3-oxo-2,6,7,8,9, 11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate
Synonym

MAP, Clinovir, Depo-Provera, Farlutal, Nidaxin, Oragest, Prodasone, Provera, Veramix
Melting Point

207-209°C
Solubility

Soluble in chloroform or acetone.

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

M1613 MSDS PDF
Info Sheet

M1613 Info Sheet PDF

References

Schindler AE, Campagnoli C, Druckmann R, et al. Classification and pharmacology of progestins. Maturitas. 2008 Sep-Oct;61(1-2):171-80. PMID: 19434889.

Meyer L, Venard C, Schaeffer V, et al. The biological activity of 3alpha-hydroxysteroid oxido-reductase in the spinal cord regulates thermal and mechanical pain thresholds after sciatic nerve injury. Neurobiol Dis. 2008 Apr;30(1):30-41. PMID: 18291663.

Poulin R, Baker D, Poirier D, et al. Androgen and glucocorticoid receptor-mediated inhibition of cell proliferation by medroxyprogesterone acetate in ZR-75-1 human breast cancer cells. Breast Cancer Res Treat. 1989 Mar;13(2):161-72. PMID: 2525057.

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