LKT Labs

Biochemicals for Life Science Research

Loperamide Hydrochloride

Product ID L5660
Cas No. 34552-83-5
Purity ≥98%
Product Unit SizeCostQuantityStock
5 g $83.40 In stock
25 g $342.80 In stock
Bulk Quote

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Description

Loperamide is a μ-opioid receptor (μOR) agonist that exhibits gastrointestinal motility modulating, anorexigenic, analgesic, and antinociceptive activities; it also potentially inhibits HCN channels. Loperamide is clinically used as an anti-diarrheal drug as it increases gastric emptying and decreases bowel water content. Loperamide also alters pain thresholds in animal models as measured by the Hargreaves paw withdrawal apparatus. Additionally, loperamide decreases foraging behavior and body weight in vivo. Loperamide also acts as a functional inhibitor of acid sphingomyelinase (FIASMA).

Product Info

Cas No.

34552-83-5
Purity

≥98%
Formula

C29H33ClN2O2 • HCl
Formula Wt.

513.51
Chemical Name

4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α- diphenyl-1-piperidinbutanamide hydrochloride
IUPAC Name

4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-N,N-dimethyl-2, 2-diphenylbutanamide;hydrochloride
Synonym

Imodium, Tebloc, Dissenten, Lopemin
Melting Point

222-223°C
Solubility

Soluble in methanol or chloroform.

Appearance

White or Almost White Crystal Powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

L5660 MSDS PDF
Info Sheet

L5660 Info Sheet PDF

References

Kumar R. Loperamide: from antidiarrheal to analgesic. J Opioid Manag. 2013 Jul-Aug;9(4):301-2. PMID: 24353024.

Kumar R, Reeta KH, Ray SB. Antinociceptive effect of intrathecal loperamide: role of mu-opioid receptor and calcium channels. Eur J Pharmacol. 2012 Dec 5;696(1-3):77-82. PMID: 23022331.

Placidi E, Marciani L, Hoad CL, et al. The effects of loperamide, or loperamide plus simethicone, on the distribution of gut water as assessed by MRI in a mannitol model of secretory diarrhoea. Aliment Pharmacol Ther. 2012 Jul;36(1):64-73. PMID: 22582872.

Chumakova YA, Bashkatova VG, Sudakov SK. Changes in feeding behavior after peripheral loperamide administration in rats. Bull Exp Biol Med. 2011 Feb;150(4):398-400. PMID: 22268026.

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