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Glucoraphanin Potassium

Product ID G4781
Cas No. 21414-41-5
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $116.00 In stock
5 mg $204.50 In stock
10 mg $395.20 In stock
25 mg $843.60 In stock
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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Glucoraphanin is a glucosinolate originally found in cruciferous vegetables of the Brassicaceae family, such as broccoli. Glucoraphanin exhibits anti-inflammatory and neuroprotective activities. In an animal model of spinal cord injury, glucoraphanin decreases histological inflammatory damage. In an animal model of restraint stress, this compound decreases stress-induced production of TNF-α and IL-1β and also increases IL-10 levels. Glucoraphanin decreases dopamine transporter degradation, expression of tyrosine hydrolase, and release of IL-1β and ROS as well as apoptosis in MPTP-induced animal models of Parkinson’s disease. In animal models of multiple sclerosis (experimental autoimmune encephalitis; EAE), glucoraphanin decreases translocation of NF-κB, release of pro-inflammatory cytokines, and apoptosis.

Weight is on anhydrous basis.

Product Info

Cas No.

21414-41-5

Purity

≥98%

Formula

C12H22KNO10S3 • xH2O

Formula Wt.

475.60

Solubility

Soluble in water.

Appearance

White to off white or yellow powder or solid

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

G4781 MSDS PDF

Info Sheet

G4781 Info Sheet PDF

References

Galuppo M, Giacoppo S, De Nicola GR, et al. RS-Glucoraphanin bioactivated with myrosinase treatment counteracts proinflammatory cascade and apoptosis associated to spinal cord injury in an experimental mouse model. J Neurol Sci. 2013 Nov 15;334(1-2):88-96. PMID: 23992921.

Galuppo M, Iori R, De Nicola GR, et al. Anti-inflammatory and anti-apoptotic effects of (RS)-glucoraphanin bioactivated with myrosinase in murine sub-acute and acute MPTP-induced Parkinson's disease. Bioorg Med Chem. 2013 Sep 1;21(17):5532-47. PMID: 23810671

Foti Cuzzola V, Galuppo M, Iori R, et al. Beneficial effects of (RS)-glucoraphanin on the tight junction dysfunction in a mouse model of restraint stress. Life Sci. 2013 Aug 28;93(7):288-305. PMID: 23871805.

Giacoppo S, Galuppo M, Iori R, et al. Protective role of (RS )-glucoraphanin bioactivated with myrosinase in an experimental model of multiple sclerosis. CNS Neurosci Ther. 2013 Aug;19(8):577-84. PMID: 23638842.

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