LKT Labs

Biochemicals for Life Science Research

Ubenimex

Ubenimex

Product ID U0618
Cas No. 58970-76-6
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $54.00 In stock
50 mg $238.00 In stock
100 mg $475.00 In stock
Bulk Quote

Quicklinks

Description

Ubenimex, also known as bestatin, is a dipeptide inhibitor of aminopeptidases such as aminopeptidase N/CD13. Bestatin displays efficacy in the treatment of lung cancer. This compound exhibits anticancer chemotherapeutic, immunomodulatory, and analgesic activities. Bestatin enhances differentiation of acute promyelotic leukemia (APL) cells. Additionally, bestatin enhances proliferation of bone marrow macrophage progenitor cells and formation of CFU-GM colonies. This compound also inhibits catabolism of opioid endopeptides.

Product Info

Cas No.

58970-76-6
Purity

≥98%
Formula

C16H24N2O4
Formula Wt.

308.37
Chemical Name

N-[(2S,3R)-3-Amino-2-hydroxy-1-oxo-4phenylbutyl]-L-leucine
IUPAC Name

(2S)-2-[[(2S, 3R)-3-amino-2-hydroxy-4-phenylbutanoyl]amino]-4-methylpentanoic acid
Synonym

Bestatin
Melting Point

233-236°C
Solubility

Soluble in acetic acid, DMSO and methanol. Less soluble in water. Insoluble in ethyl acetate, benzene, hexane and chloroform.
Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

U0618 MSDS PDF
Info Sheet

U0618 Info Sheet PDF

References

Hitzerd SM, Verbrugge SE, Ossenkoppele G, et al. Positioning of aminopeptidase inhibitors in next generation cancer therapy. Amino Acids. 2014 Apr;46(4):793-808. PMID: 24385243.

Qian X, He J, Zhao Y, et al. Inhibition of p38 MAPK Phosphorylation Is Critical for Bestatin to Enhance ATRA-Induced Cell Differentiation in Acute Promyelocytic Leukemia NB4 Cells. Am J Ther. 2013 Oct 17. [Epub ahead of print]. PMID: 24141198.

Jia MR, Wei T, Xu WF. The Analgesic Activity of Bestatin as a Potent APN Inhibitor. Front Neurosci. 2010 Jun 28;4:50. PMID: 20631848.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • E6235

    Epirubicin Hydrochloride

    Anthracycline, DNA intercalator; topoisomerase ...

    ≥90%
  • G3358

    Ginkgolide ABC

    Mixture of Ginkgolides A, B and C, found in Gin...

    ≥98%
  • B3211

    (+)-Bicuculline

    NMDA potentiator, GABA-A antagonist.

    ≥98%
  • A4805

    Amastatin Hydrochloride Hydrate

    Aminopeptidase inhibitor.

    ≥98%
  • G3453

    20(S)-Ginsenoside Rh2

    Triterpene saponin found in Panax.

    ≥98%
  • K7600

    KT5720

    PKA and PDK1 inhibitor, HCN channel blocker, po...

    ≥98%
  • F4501

    Flavanone

    Variety of flavonoid found in various plant sou...

    ≥98%
  • R0272

    Rasagiline Mesylate

    MAO-A/B inhibitor.

    ≥98%
  • A5135

    Aminophylline Dihydrate

    Xanthine derivative; adenosine antagonist, PDE ...

    ≥98%
  • T0101

    7-epi-10-Deacetyltaxol

    Taxane found in Taxus; potential microtubule de...

    ≥98%
  • S8013

    [Tyr8]-Substance P

    Endogenous tachykinin peptide, involved in infl...

    ≥95%
  • D1774

    Desloratadine

    Loratadine metabolite; FIASMA, histamine H1 ant...

    ≥97%
  • G8850

    GW-5074

    c-Raf inhibitor.

    ≥98%
  • C6982

    Crustacean Cardioactive Peptide

    Neuropeptide hormone found in arthropods.

    ≥95%
  • A822686

    Aureothricin

    Aureothricin is a member of the dithiolopyrrolo...

    ≥98%
  • P2510

    4-Phenylbutylisothiocyanate

    Synthetic ITC.

    ≥98%
  • T0092

    1-Hydroxybaccatin I

    Diterpene found in Taxus; potential microtubule...

    ≥96%
  • A761003

    AT-7519 Hydrochloride

    ATP competitive CDK inhibitor.

    ≥98%
  • D1849

    4′-Demethylepipodophyllotoxin

    Podophyllotoxin derivative found in Podophyllum...

    ≥98%
  • T0140

    TAK-632

    RAF inhibitor.

    ≥99%