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Mycophenolate Mofetil

Product ID M964098
Cas No. 128794-94-5
Purity ≥98%
Product Unit SizeCostQuantityStock
50 mg $51.10 In stock
100 mg $77.10 In stock
250 mg $187.20 In stock
500 mg $323.20 In stock
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  • Description
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Description

Mycophenolate mofetil is a prodrug of the compound mycophenolic acid which depletes activated B and T lymphocytes. Mycophenolate mofetil has previously been used in preventing organ transplant rejection and has also been shown to attenuate lupus erythematosus and prolong life in a mouse model of autoimmune disease. Studies have also shown that treatment of a mouse model of Crohn’s disease with mycophenolate mofetil results in deactivation of the inflammatory response, improvement of histologic changes, and regulation of cytokine production by modulating of Th1/Th1 cell differentiation. In a diabetic mouse model, mycophenolate mofetil treatment was found to attenuate diabetic nephropathy independent of glycemic control.

Product Info

Cas No.

128794-94-5

Purity

≥98%

Formula

C23H31NO7

Formula Wt.

433.50

IUPAC Name

2-morpholin-4-ylethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1H-2-benzofuran-5-yl)-4-methylhex-4-enoate

Synonym

TM-MMF, RS61443; RS-61443

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

M964098 MSDS PDF

Info Sheet

M964098 Info Sheet PDF

References

Lee HK, Kim KH, Kim HS, et al. Effect of a combination of prednisone or mycophenolate mofetil and mesenchymal stem cells on lupus symptoms in MLR.FasIpr mice. Stem Cells Int. 2018 Jul 3;2018:4273107. PMID: 30057623.

Taylor EB, Ryan MJ. Immunosuppression with mycophenolate mofetil attenuates hypertension in an experimental model of autoimmune disease. J Am Heart Assoc. 2017 Feb 27;6(3):pii:e005394. PMID: 28242635.

Lv QK, Liu JX, Li SN, et al. Mycophenolate mofetil modulates differentiation of Th1/Th2 and the secretion of cytokines in an active Crohn’s disease mouse model. Int J Mol Sci. 2015 Nov 6;16(11):26654-26666. PMID: 26561804.

Seo JW, Kim YG, Lee SH, et al. Mycophenolate mofetil ameliorates diabetic nephropathy in db/db mice. Biomed Res Int. 2015;2015:310627. PMID: 26345532.

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