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Fluvoxamine Maleate

Fluvoxamine Maleate

Product ID F4783
Cas No. 61718-82-9
Purity ≥97%
Product Unit SizeCostQuantityStock
25 mg $82.70 In stock
100 mg $248.10 In stock
500 mg $551.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Fluvoxamine is a selective serotonin (5-HT) reuptake inhibitor (SSRI) that exhibits antidepressant, anti-inflammatory, cardioprotective, and antioxidative activities. Fluvoxamine inhibits the serotonin transporter (SERT) and also activates pre-synaptic 5-HT3 receptors; this increases Ca2+ levels and activates σ1 receptors, modulating intracellular Ca2+ levels and inducing glutamate release in vivo. In cellular models, fluvoxamine inhibits production of NO and TNF-α. Fluvoxamine displays cardioprotective benefit in animal models by preventing transverse aortic constriction (TAC)-induced myocardial hypertrophy and impaired left ventricle fractional shortening. In other animal models, this compound increases levels of glutathione and decreases levels of malondialdehyde and myeloperoxidase. Fluvoxamine may also induce bone loss, as it inhibits osteoclast formation and resorption and prevents bone mineralization by osteoblasts. This compound also acts as a functional inhibitor of acid sphingomyelinase (FIASMA).

Product Info

Cas No.

61718-82-9

Purity

≥97%

Formula

C15H21O2N2F3 • C4H4O4

Formula Wt.

434.41

Chemical Name

(E)-5-Methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanone-O-(2-aminoethyl)oxime maleate

IUPAC Name

(Z)-but-2-enedioic acid;2-[(E)-[5-methoxy-1-[4-(trifluoromethyl)phenyl]pentylidene]amino] oxyethanamine

Synonym

MK-264, NSC309469

Melting Point

120-121.5°C

Appearance

White to off white powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

F4783 MSDS PDF

Info Sheet

F4783 Info Sheet PDF

References

Hodge JM, Wang Y, Berk M, et al. Selective serotonin reuptake inhibitors inhibit human osteoclast and osteoblast formation and function. Biol Psychiatry. 2013 Jul 1;74(1):32-9. PMID: 23260229.

Fu Y, Yu S, Guo X, et al. Fluvoxamine increased glutamate release by activating both 5-HT(3) and sigma-1 receptors in prelimbic cortex of chronic restraint stress C57BL/6 mice. Biochim Biophys Acta. 2012 Apr;1823(4):826-37. PMID: 22306004.

Tynan RJ, Weidenhofer J, Hinwood M, et al. A comparative examination of the anti-inflammatory effects of SSRI and SNRI antidepressants on LPS stimulated microglia. Brain Behav Immun. 2012 Mar;26(3):469-79. PMID: 22251606.

Tagashira H, Bhuiyan S, Shioda N, et al. Sigma1-receptor stimulation with fluvoxamine ameliorates transverse aortic constriction-induced myocardial hypertrophy and dysfunction in mice. Am J Physiol Heart Circ Physiol. 2010 Nov;299(5):H1535-45. PMID: 20802134.

Dursun H, Bilici M, Albayrak F, et al. Antiulcer activity of fluvoxamine in rats and its effect on oxidant and antioxidant parameters in stomach tissue. BMC Gastroenterol. 2009 May 20;9:36. PMID: 19457229.

Custom Order

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