Name: Entecavir Hydrate
SKU: E5578
Availability: InStock

Description

Entecavir is a cyclopentane class nucleoside analog of deoxyguanosine. Entecavir exhibits antiviral activity and is used clinically to treat hepatitis B infections. Entecavir binds to reverse transcriptase and gets incorporated into DNA, causing chain termination and preventing protein synthesis. This compound may also inhibit HIV-1 reverse transcriptase as well.

Product Info

Cas No.	209216-23-9
Purity	≥99%
Formula	C₁₂H₁₇N₅O₄
Formula Wt.	295.29
Appearance	White powder

Shipping and Storage

Store Temp	Ambient
Ship Temp	Ambient

Downloads

Info Sheet	E5578 Info Sheet PDF

References

Yurdaydin C. Entecavir: a step forward in combating hepatitis B disease. Expert Opin Pharmacother. 2008 Dec;9(17):3095-109. PMID: 19006481.

Cheng PN, Chang TT. Entecavir: a potent antiviral with minimal long-term resistance in nucleoside-naive chronic hepatitis B patients. Expert Rev Anti Infect Ther. 2008 Oct;6(5):569-79. PMID: 18847396.

Domaoal RA, McMahon M, Thio CL, et al. Pre-steady-state kinetic studies establish entecavir 5'-triphosphate as a substrate for HIV-1 reverse transcriptase. J Biol Chem. 2008 Feb 29;283(9):5452-9. PMID: 17962184.

Langley DR, Walsh AW, Baldick CJ, et al. Inhibition of hepatitis B virus polymerase by entecavir. J Virol. 2007 Apr;81(8):3992-4001. PMID: 17267485.

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Entecavir Hydrate

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