Xenopsin is a neurotensin-related octapeptide hormone originally found in amphibians. Xenopsin exhibits anti-inflammatory activity, decreasing vascular leakage in animal models of edema/inflammation. Xenopsin also increases firing rates of dopaminergic neurons. In ileal smooth muscle cells, xenopsin induces relaxation. Xenopsin also increases insulin release in pancreatic β-cells and stimulates meal-dependent exocrine pancreatic secretion.
| Cas No. | 51827-01-1 |
|---|---|
| Purity | ≥95% |
| Formula | C47H73N13O10 |
| Formula Wt. | 980.19 |
| IUPAC Name | (2S)-2-[[(3S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-6-amino-2-[[2-[[(2S)-5-oxopyrrolidine-2-carbonyl]amino]acetyl]amino]hexanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-methylpentanoyl]amino]-4-methylpentanoic acid |
| Solubility | Soluble in DMSO, water. |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| Info Sheet |
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Zahid OK, Mechkarska M, Ojo OO, et al. Caerulein-and xenopsin-related peptides with insulin-releasing activities from skin secretions of the clawed frogs, Xenopus borealis and Xenopus amieti (Pipidae). Gen Comp Endocrinol. 2011 Jun 1;172(2):314-20. PMID: 21458457.
Clemens A, Katsoulis S, Nustede R, et al. Relaxant effect of xenin on rat ileum is mediated by apamin-sensitive neurotensin-type receptors. Am J Physiol. 1997 Jan;272(1 Pt 1):G190-6. PMID: 9038893.
Gao GC, Wei ET. Xenopsin, neurotensin, neurotensin(8-13) and N-acetyl-neurotensin(8-13) inhibit vascular leakage in rats after tissue injury. J Pharmacol Exp Ther. 1993 May;265(2):619-25. PMID: 8496813.
Feurle GE, Hamscher G, Kusiek R, et al. Identification of xenin, a xenopsin-related peptide, in the human gastric mucosa and its effect on exocrine pancreatic secretion. J Biol Chem. 1992 Nov 5;267(31):22305-9. PMID: 1429581.
Pozza MF, Küng E, Bischoff S, et al. The neurotensin analog xenopsin excites nigral dopamine neurons. Eur J Pharmacol. 1988 Jan 19;145(3):341-3. PMID: 3350051.
