Description
Nitisinone is a nitrobenzene inhibitor of HPPD, an enzyme involved in tyrosine degradation. Nitisinone is clinically used to slow the effects of hereditary type 1 tyrosinemia and as a potential treatment for alkaptonuria.
Nitisinone
Product ID N3476
Cas No. 104206-65-7
Purity ≥99%
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Product Info
| Cas No. | 104206-65-7 |
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| Purity | ≥99% |
| Formula | C14H10F3NO5 |
| Formula Wt. | 329.23 |
| IUPAC Name | 2-[2-nitro-4-(trifluoromethyl)benzoyl]cyclohexane-1,3-dione |
| Synonym | NTBC, orfadin |
| Solubility | DMSO: ≥5 mg/mL, Soluble in Chloroform |
| Appearance | Light Yellow Powder |
Shipping and Storage
| Store Temp | 4°C |
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| Ship Temp | Ambient |
Downloads
| MSDS | |
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| Info Sheet |
References
McKiernan PJ. Nitisinone in the treatment of hereditary tyrosinaemia type 1. Drugs. 2006;66(6):743-50. PMID: 16706549.
Kavana M, Moran GR. Interaction of (4-hydroxyphenyl)pyruvate dioxygenase with the specific inhibitor 2-[2-nitro-4-(trifluoromethyl)benzoyl]-1,3-cyclohexanedione. Biochemistry. 2003 Sep 2;42(34):10238-45. PMID: 12939152.
Phornphutkul C, Introne WJ, Perry MB, et al. Natural history of alkaptonuria. N Engl J Med. 2002 Dec 26;347(26):2111-21. PMID: 12501223.