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Mastoparan 8

Mastoparan 8

Product ID M0273
Cas No.
Purity ≥95%
Product Unit SizeCostQuantityStock
0.5 mg $81.70 In stock
1 mg $138.90 In stock
2.5 mg $245.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Mastoparan 8 is an antimicrobial peptide (AMP) derived from the venom of bees and wasps that activates Gi/o GPCRs. Mastoparan 8 is an analog of mastoparan with similar activity, including inducing mast cell degranulation and stimulating insulin secretion.

Product Info

Purity

≥95%

Formula

C70H131N21O15

Formula Wt.

1506.96

Synonym

Mas8, Mastoparan-M, Mast cell-degranulating peptide.

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

M0273 MSDS PDF

Info Sheet

M0273 Info Sheet PDF

References

dos Santos LD, Aparecido dos Santos Pinto JR, Menegasso AR, et al. Proteomic profiling of the molecular targets of interactions of the mastoparan peptide Protopolybia MP-III at the level of endosomal membranes from rat mast cells. Proteomics. 2012 Aug;12(17):2682-93. PMID: 22761183.

Cabrera MP, Alvares DS, Leite NB, et al. New insight into the mechanism of action of wasp mastoparan peptides: lytic activity and clustering observed with giant vesicles. Langmuir. 2011 Sep 6;27(17):10805-13. PMID: 21797216.

Etzerodt T, Henriksen JR, Rasmussen P, et al. Selective acylation enhances membrane charge sensitivity of the antimicrobial peptide mastoparan-x. Biophys J. 2011 Jan 19;100(2):399-409. PMID: 21244836.

Todokoro Y, Yumen I, Fukushima K, et al. Structure of tightly membrane-bound mastoparan-X, a G-protein-activating peptide, determined by solid-state NMR. Biophys J. 2006 Aug 15;91(4):1368-79. PMID: 16714348.

Amin RH, Chen HQ, Veluthakal R, et al. Mastoparan-induced insulin secretion from insulin-secreting betaTC3 and INS-1 cells: evidence for its regulation by Rho subfamily of G proteins. Endocrinology. 2003 Oct;144(10):4508-18. PMID: 12960065.

Armstead WM. Protein kinase C activation generates superoxide and contributes to impairment of cerebrovasodilation induced by G protein activation after brain injury. Brain Res. 2003 May 9;971(2):153-60. PMID: 12706231.

Kowluru A. Identification and characterization of a novel protein histidine kinase in the islet beta cell: evidence for its regulation by mastoparan, an activator of G-proteins and insulin secretion. Biochem Pharmacol. 2002 Jun 15;63(12):2091-100. PMID: 12110368.

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