LKT Labs

Biochemicals for Life Science Research

Biochanin A

Product ID B3358
Cas No. 491-80-5
Purity ≥98%
Product Unit SizeCostQuantityStock
100 mg $65.30 In stock
250 mg $119.10 In stock
1 g $190.90 In stock
Bulk Quote

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Description

Biochanin A is an isoflavone/flavonoid found in plants in the Fabaceae family, such as clover, soy, and alfalfa. Biochanin A exhibits anticancer, anti-metastatic, estrogenic, neuroprotective, anti-osteoporotic, antiviral, and anti-inflammatory activities. Biochanin A may activate PPARα and PPARγ. In pancreatic cancer cells, biochanin A inhibits cellular proliferation, migration, and invasion, and suppresses activation of Akt and MAPKs. In other cellular models, biochanin A acts as a phytoestrogen and increases expression of ERβ. Biochanin A also improves cognitive deficits in animal models of Alzheimer’s disease. In stem cells, this compound inhibits adipocyte differentiation and increases osteoblast differentiation. Additionally, biochanin A inhibits replication of influenza virus and suppresses production of IL-6, IL-8, IL-10, and TNF-α in vitro.

Product Info

Cas No.

491-80-5
Purity

≥98%
Formula

C16H12O5
Formula Wt.

284.27
IUPAC Name

5,7-dihydroxy-3-(4-methoxyphenyl)chromen-4-one
Synonym

4'-Methylgenistein, Biochanin
Melting Point

210-213°C
Solubility

Soluble in acetone, chloroform, methanol, DMSO (55 mg/mL), ethanol (9 mg/mL).
Appearance

White Crystal Powder

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

B3358 MSDS PDF
Info Sheet

B3358 Info Sheet PDF
Brochures

Natural Products Booklet

References

Wang L, Waltenberger B, Pferschy-Wenzig EM, et al. Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARγ): a review. Biochem Pharmacol. 2014 Jul 30. [Epub ahead of print]. PMID: 25083916.

Biradar SM, Joshi H, Chheda TK. Biochanin-A ameliorates behavioural and neurochemical derangements in cognitive-deficit mice for the betterment of Alzheimer's disease. Hum Exp Toxicol. 2014 Apr;33(4):369-82. PMID: 23900307.

Bhardwaj V, Tadinada SM, Jain A, et al. Biochanin A reduces pancreatic cancer survival and progression. Anticancer Drugs. 2014 Mar;25(3):296-302. PMID: 24201306.

Nynca A, Swigonska S, Piasecka J, et al. Biochanin A affects steroidogenesis and estrogen receptor-β expression in porcine granulosa cells. Theriogenology. 2013 Oct 15;80(7):821-8. PMID: 23953692.

Su SJ, Yeh YT, Su SH, et al. Biochanin a promotes osteogenic but inhibits adipogenic differentiation: evidence with primary adipose-derived stem cells. Evid Based Complement Alternat Med. 2013;2013:846039. PMID: 23843885.

Sithisarn P, Michaelis M, Schubert-Zsilavecz M, et al. Differential antiviral and anti-inflammatory mechanisms of the flavonoids biochanin A and baicalein in H5N1 influenza A virus-infected cells. Antiviral Res. 2013 Jan;97(1):41-8. PMID: 23098745.

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