Alsterpaullone

Product ID A4577

Cas No. 237430-03-4

Purity ≥98%

Unit Size	Cost	Quantity		Stock

Bulk Quote

Add to Wishlist

Quicklinks

Description
Product Info
Shipping and Storage
Downloads
References

Description
Product Info
Shipping and Storage
Downloads
References
Custom Order

Description

Alsterpaullone exhibits anticancer, anti-angiogenic, antiviral, and neuroprotective activities. Alsterpaullone inhibits cyclin-dependent kinases (CDKs), inducing G2/M phase cell cycle arrest and apoptosis in leukemia cells. Additionally, alsterpaullone inhibits glycogen synthase kinase 3 (GSK-3), inducing Wnt signaling; in ticks, this results in anti-fertility potential, decreasing egg hatching activity. Alsterpaullone also inhibits HIV-1 replication and proliferation. In ex vivo models of Alzheimer’s disease, this compound protects against neuronal death and decreases phosphorylation of tau protein.

Product Info

Cas No.	237430-03-4
Purity	≥98%
Formula	C₁₆H₁₁N₃O₃
Formula Wt.	293.28
IUPAC Name	9-nitro-7,12-dihydro-5H-indolo[3,2-d][1]benzazepin-6-one
Synonym	9-Nitro-7,12-dihydroindolo-[3,2-d][1]benzazepin-6(5)-one
Solubility	Soluble in DMSO.
Appearance	Yellow to Brown Powder

Shipping and Storage

Store Temp	4°C
Ship Temp	Ambient

Downloads

MSDS	A4577 MSDS PDF
Info Sheet	A4577 Info Sheet PDF

References

Cui C, Wang Y, Wang Y, et al. Alsterpaullone, a Cyclin-Dependent Kinase Inhibitor, Mediated Toxicity in HeLa Cells through Apoptosis-Inducing Effect. J Anal Methods Chem. 2013;2013:602091. PMID: 23577282.

Windsor PJ, Leys SP. Wnt signaling and induction in the sponge aquiferous system: evidence for an ancient origin of the organizer. Evol Dev. 2010 Sep-Oct;12(5):484-93. PMID: 20883217.

Zahler S, Liebl J, Fürst R, et al. Anti-angiogenic potential of small molecular inhibitors of cyclin dependent kinases in vitro. Angiogenesis. 2010 Sep;13(3):239-49. PMID: 20706783.

Fabres A, De Andrade CP, Guizzo M, et al. Effect of GSK-3 activity, enzymatic inhibition and gene silencing by RNAi on tick oviposition and egg hatching. Parasitology. 2010 Sep;137(10):1537-46. PMID: 20500916.

Guendel I, Agbottah ET, Kehn-Hall K, et al. Inhibition of human immunodeficiency virus type-1 by cdk inhibitors. AIDS Res Ther. 2010 Mar 24;7(1):7. PMID: 20334651.

Selenica ML, Jensen HS, Larsen AK, et al. Efficacy of small-molecule glycogen synthase kinase-3 inhibitors in the postnatal rat model of tau hyperphosphorylation. Br J Pharmacol. 2007 Nov;152(6):959-79. PMID: 17906685.