LKT Labs

Biochemicals for Life Science Research

INK128

INK128

Product ID I5440
Cas No. 1224844-38-5
Purity ≥99%
Product Unit SizeCostQuantityStock
1 mg $72.00 In stock
5 mg $135.10 In stock
25 mg $390.70 Please Inquire
Bulk Quote

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Description

INK-128 is an ATP-competitive inhibitor of mTOR, inhibiting both mTORC1 and mTORC2, protein complexes that modulate cell growth, cell survival, and cell migration. This compound displays anticancer chemotherapeutic and anti-metastatic activities in both in vitro and in vivo models. In vitro, INK-128 inhibits cell migration and adhesion, processes critical for the invasive nature of multiple myeloma; INK-128 also inhibits proliferation and decreases colony formation in an in vitro model of B-cell acute lymphoblastic leukemia. In vivo, INK-128 decreased metastases in an animal model of prostate cancer. This compound is currently in clinical trials as a potential treatment for multiple myeloma.

Product Info

Cas No.

1224844-38-5
Purity

≥99%
Formula

C15H15N7O
Formula Wt.

309.33
Chemical Name

5-(4-amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)-1, 3-benzoxazol-2-amine
IUPAC Name

5-(4-amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)-1, 3-benzoxazol-2-amine
Synonym

MLN-0128, Sapanisertib
Solubility

DMSO 62 mg/mL (200.43 mM) Ethanol 2 mg/mL (6.46 mM) Water Insoluble
Appearance

pink powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

I5440 MSDS PDF
Info Sheet

I5440 Info Sheet PDF
Brochures

PI3K-Akt-mTORC Pathway Booklet

References

Janes MR, Vu C, Mallya S, et al. Efficacy of the investigational mTOR kinase inhibitor MLN0128/INK128 in models of B-cell acute lymphoblastic leukemia. Leukemia. 2013 Mar;27(3):586-94. PMID: 23090679.

Hsieh AC, Liu Y, Edlind MP, et al. The translational landscape of mTOR signalling steers cancer initiation and metastasis. Nature. 2012 Feb 22;485(7396):55-61. PMID: 22367541.

Maiso P, Liu Y, Morgan B, et al. Defining the role of TORC1/2 in multiple myeloma. Blood. 2011 Dec 22;118(26):6860-70. PMID: 22045983.

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