Amoxapine

Name: Amoxapine
SKU: A5059
Availability: InStock

Product ID A5059

Cas No. 14028-44-5

Purity ≥98%

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Product Info
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Description

Amoxapine is a tricyclic antidepressant that acts as an antagonist at 5-HT2/3/6/7 receptors, D2/3/4 receptors, H1 histamine receptors, α1-adrenergic receptors, and also on the serotonin transporter (SERT) and norepinephrine transporter (NET). Amoxapine also acts as an antagonist at hERG K+ channels, potentially prolonging the cardiac QT interval. Amoxapine exhibits antidepressant, antipsychotic, and antibacterial activities. Amoxapine inhibits GABA- and NMDA-induced increases in intracellular Ca2+ levels and increases leu-enkephalin levels in vivo. This compound exhibits antibiotic activity through inhibition of bacterial β-glucuronidase.

Product Info

Cas No.	14028-44-5
Purity	≥98%
Formula	C₁₇H₁₆ClN₃O
Formula Wt.	313.78
Chemical Name	8-chloro-6-piperazin-1-ylbenzo[b][1,4]benzoxazepine
IUPAC Name	8-chloro-6-piperazin-1-ylbenzo[b][1,4]benzoxazepine
Melting Point	175.5C
Appearance	Yellow crystalline powder

Shipping and Storage

Store Temp	Ambient
Ship Temp	Ambient

Downloads

MSDS	A5059 MSDS PDF
Info Sheet	A5059 Info Sheet PDF

References

Ahmad S, Hughes MA, Yeh LA, et al. Potential repurposing of known drugs as potent bacterial β-glucuronidase inhibitors. J Biomol Screen. 2012 Aug;17(7):957-65. PMID: 22535688.

Yang G, Zhou MH, Ren Z, et al. Amoxapine inhibits delayed outward rectifier K(+) currents in cerebellar granule cells via dopamine receptor and protein kinase A activation. Cell Physiol Biochem. 2011;28(1):163-74. PMID: 21865859.

Obers S, Staudacher I, Ficker E, et al. Multiple mechanisms of hERG liability: K+ current inhibition, disruption of protein trafficking, and apoptosis induced by amoxapine. Naunyn Schmiedebergs Arch Pharmacol. 2010 May;381(5):385-400. PMID: 20229012.

Chaudhry IB, Husain N, Khan S, et al. Amoxapine as an antipsychotic: comparative study versus haloperidol. J Clin Psychopharmacol. 2007 Dec;27(6):575-81. PMID: 18004123.

Takebayashi M, Kagaya A, Inagaki M, et al. Effects of antidepressants on gamma-aminobutyric acid- and N-methyl-D-aspartate-induced intracellular Ca(2+) concentration increases in primary cultured rat cortical neurons. Neuropsychobiology. 2000;42(3):120-6. PMID: 11015029.

Roth BL, Craigo SC, Choudhary MS, et al. Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors. J Pharmacol Exp Ther. 1994 Mar;268(3):1403-10. PMID: 7908055.

Gozlan H, Saddiki-Traki F, Merahi N, et al. Preclinical pharmacology of amoxapine and amitriptyline. Implications of serotoninergic and opiodergic systems in their central effect in rats. Encephale. 1991 Dec;17 Spec No 3:415-22. PMID: 1666997.

Hamon M, Gozlan H, Bourgoin S, et al. Opioid receptors and neuropeptides in the CNS in rats treated chronically with amoxapine or amitriptyline. Neuropharmacology. 1987 Jun;26(6):531-9. PMID: 3037421.