LKT Labs

Biochemicals for Life Science Research

Mevinolin

Product ID M1687
Cas No. 75330-75-5
Purity ≥97%
Product Unit SizeCostQuantityStock
50 mg $104.20 In stock
100 mg $173.70 In stock
500 mg $405.20 In stock
5 g $1,312.50 In stock
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Description

Mevinolin (lovastatin) is a synthetic statin that is also produced by oyster mushrooms and some varieties of rice. Lovastatin inhibits HMG-CoA reductase, preventing cholesterol synthesis; it exhibits anti-hyperlipidemic, anticancer, and antiviral activities. In vitro, lovastatin inhibits proliferation of lymphoma cells, decreasing expression of ROS and transient receptor potential canonical 6 (TRPC6) channels. Additionally, lovastatin inhibits coxsackievirus replication, decreasing expression of coxsackie and adenovirus receptors and preventing viral entry.

Product Info

Cas No.

75330-75-5

Purity

≥97%

Formula

C24H36O5

Formula Wt.

404.54

Chemical Name

(2S)-2-Methylbutanoic acid (1S,3R,7S,8S,8aR)-1,2,3,7,- 8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalen- yl ester

IUPAC Name

[(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3, 7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate

Synonym

Mevacor, MK-803, Lovalip, Mevinacor, Mevlor, Sivlor, Lovastatin

Melting Point

174.5°C

Solubility

Soluble in acetone and chloroform. Slightly soluble in DMSO (8mg/mL),methanol and ethanol(6mg/mL). Insoluble in water.

Appearance

White to off-white crystalline powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

M1687 MSDS PDF

Info Sheet

M1687 Info Sheet PDF

Brochures

Statins Flyer

References

Song X, Liu BC, Lu XY, et al. Lovastatin inhibits human B lymphoma cell proliferation by reducing intracellular ROS and TRPC6 expression.
Biochim Biophys Acta. 2014 May;1843(5):894-901. PMID: 24518247.

Werner B, Dittmann S, Funke C, et al. Effect of lovastatin on coxsackievirus B3 infection in human endothelial cells. Inflamm Res. 2014 Apr;63(4):267-76. PMID: 24316867.

Gunde-Cimerman N, Cimerman A. Pleurotus fruiting bodies contain the inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase-lovastatin. Exp Mycol. 1995 Mar;19(1):1-6. PMID: 7614366.

Alberts AW. Discovery, biochemistry and biology of lovastatin. Am J Cardiol. 1988 Nov 11;62(15):10J-15J. PMID: 3055919.

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