Dermorphin is an opioid peptide originally found in the skin of amphibians; it exhibits analgesic and antinociceptive activities, acting as an agonist at μ-opioid receptors (μORs). In animal models of thermal, mechanical, and chemical pain, dermorphin increases pain thresholds.
| Cas No. | 77614-16-5 |
|---|---|
| Purity | ≥96% |
| Formula | C40H50N8O10 |
| Formula Wt. | 802.88 |
| Chemical Name | Tyrosyl-alanyl-phenylalanyl-glycyl-tyrosyl-prolyl-serinamide |
| IUPAC Name | (2S)-N-[(2S)-1-amino-3-hydroxy-1-oxopropan-2-yl]-1-[(2S)-2-[[2-[[(2S)-2- [[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl] amino]-3-phenylpropanoyl]amino]acetyl]amino]-3-(4-hydroxyphenyl) propanoyl]pyrrolidine-2-carboxamide |
| Solubility | Slightly soluble in water. |
| Appearance | White to off white powder |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | |
|---|---|
| Info Sheet |
Mizoguchi H, Bagetta G, Sakurada T, et al. Dermorphin tetrapeptide analogs as potent and long-lasting analgesics with pharmacological profiles distinct from morphine. Peptides. 2011 Feb;32(2):421-7. PMID: 21126548.
Guzevatykh LS, Voronina TA, Emel'ianova TG, et al. Comparative analysis of analgesic activities of dermorphin, [DPro6]-dermorphin, and their C-terminal tripeptides. Izv Akad Nauk Ser Biol. 2007 Sep-Oct;(5):577-82. PMID: 18038625.
