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Olaparib

Olaparib

Product ID O4402
Cas No. 763113-22-0
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $81.70 In stock
10 mg $110.50 In stock
25 mg $153.10 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Olaparib is an inhibitor of poly(ADP-ribose) polymerase (PARP 1/2) that prevents DNA repair. Olaparib displays benefit in clinical trials of BRCA mutation-harboring ovarian and breast cancers as well as prostate, pancreatic, and non-small cell lung cancers (NSCLC). In animal models with ovarian cancer xenografts, olaparib increases apoptosis and decreases proliferation to inhibit tumor growth.

Product Info

Cas No.

763113-22-0

Purity

≥98%

Formula

C24H23FN4O3

Formula Wt.

434.47

Chemical Name

4-[[3-[4-(cyclopropanecarbonyl)piperazine-1-carbonyl]-4-fluorophenyl] methyl]-2H-phthalazin-1-one

IUPAC Name

4-[[3-[4-(cyclopropanecarbonyl)piperazine-1-carbonyl]-4-fluorophenyl] methyl]-2H-phthalazin-1-one

Synonym

AZD2281, KU-0059436, Lynparza

Solubility

DMSO (10 mg/ml), DMF (3 mg/ml)

Appearance

White to off white powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

O4402 MSDS PDF

Info Sheet

O4402 Info Sheet PDF

Brochures

PARP Inhibitors Flyer

References

Lee JM, Ledermann JA, Kohn EC. PARP Inhibitors for BRCA1/2 mutation-associated and BRCA-like malignancies. Ann Oncol. 2013 Nov 12. [Epub ahead of print]. PMID: 24225019.

Olaparib Enters Phase III Clinical Testing. Cancer Discov. 2013 Nov;3(11):1210. PMID: 24203936.

Postel-Vinay S, Bajrami I, Friboulet L, et al. A high-throughput screen identifies PARP1/2 inhibitors as a potential therapy for ERCC1-deficient non-small cell lung cancer. Oncogene. 2013 Nov 21;32(47):5377-87. PMID: 23934192.

Kortmann U, McAlpine JN, Xue H, et al. Tumor growth inhibition by olaparib in BRCA2 germline-mutated patient-derived ovarian cancer tissue xenografts. Clin Cancer Res. 2011 Feb 15;17(4):783-91. PMID: 21097693.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
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