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9-Aminocamptothecin Hydrochloride

Product ID A491337
Cas No. 91421-43-1 (free base)
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $64.90 In stock
10 mg $291.10 In stock
25 mg $606.30 In stock
50 mg $1,010.40 In stock
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  • Description
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Description

9-amino-Camptothecin is a camptothecin derivative. Camptothecin is a quinolone alkaloid precursor of irinotecan; it is originally found in Camptotheca. Camptothecin exhibits anticancer chemotherapeutic activity, inhibiting topoisomerase I and inducing double-stranded DNA breaks. Camptothecin is extremely cytotoxic and only its derivatives are clinically used as chemotherapeutics.

Product Info

Cas No.

91421-43-1 (free base)

Purity

≥98%

Formula

C20H17N3O4 • HCl

Formula Wt.

399.83

Synonym

9-Amino-20-camptothecin HCl; 9-AC HCl

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

A491337 MSDS PDF

Info Sheet

A491337 Info Sheet PDF

References

Rodríguez-Berna G, Mangas-Sanjuán V, Gonzalez-Alvarez M, et al. A promising camptothecin derivative: Semisynthesis, antitumor activity and intestinal permeability. Eur J Med Chem. 2014 Jun 25;83C:366-373. PMID: 24980118.

Berniak K, Rybak P, Bernas T, et al. Relationship between DNA damage response, initiated by camptothecin or oxidative stress, and DNA replication, analyzed by quantitative 3D image analysis. Cytometry A. 2013 Jul 11. [Epub ahead of print]. PMID: 23846844.

Redinbo MR, Stewart L, Kuhn P, et al. Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA. Science. 1998 Mar 6;279(5356):1504-13. PMID: 9488644.

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