LKT Labs

Biochemicals for Life Science Research

Alsterpaullone

Alsterpaullone

Product ID A4577
Cas No. 237430-03-4
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $162.00 In stock
5 mg $623.00 In stock
Bulk Quote

Quicklinks

Description

Alsterpaullone exhibits anticancer, anti-angiogenic, antiviral, and neuroprotective activities. Alsterpaullone inhibits cyclin-dependent kinases (CDKs), inducing G2/M phase cell cycle arrest and apoptosis in leukemia cells. Additionally, alsterpaullone inhibits glycogen synthase kinase 3 (GSK-3), inducing Wnt signaling; in ticks, this results in anti-fertility potential, decreasing egg hatching activity. Alsterpaullone also inhibits HIV-1 replication and proliferation. In ex vivo models of Alzheimer’s disease, this compound protects against neuronal death and decreases phosphorylation of tau protein.

Product Info

Cas No.

237430-03-4
Purity

≥98%
Formula

C16H11N3O3
Formula Wt.

293.28
IUPAC Name

9-nitro-7,12-dihydro-5H-indolo[3,2-d][1]benzazepin-6-one
Synonym

9-Nitro-7,12-dihydroindolo-[3,2-d][1]benzazepin-6(5)-one
Solubility

Soluble in DMSO.
Appearance

Yellow to Brown Powder

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

A4577 MSDS PDF
Info Sheet

A4577 Info Sheet PDF

References

Cui C, Wang Y, Wang Y, et al. Alsterpaullone, a Cyclin-Dependent Kinase Inhibitor, Mediated Toxicity in HeLa Cells through Apoptosis-Inducing Effect. J Anal Methods Chem. 2013;2013:602091. PMID: 23577282.

Windsor PJ, Leys SP. Wnt signaling and induction in the sponge aquiferous system: evidence for an ancient origin of the organizer. Evol Dev. 2010 Sep-Oct;12(5):484-93. PMID: 20883217.

Zahler S, Liebl J, Fürst R, et al. Anti-angiogenic potential of small molecular inhibitors of cyclin dependent kinases in vitro. Angiogenesis. 2010 Sep;13(3):239-49. PMID: 20706783.

Fabres A, De Andrade CP, Guizzo M, et al. Effect of GSK-3 activity, enzymatic inhibition and gene silencing by RNAi on tick oviposition and egg hatching. Parasitology. 2010 Sep;137(10):1537-46. PMID: 20500916.

Guendel I, Agbottah ET, Kehn-Hall K, et al. Inhibition of human immunodeficiency virus type-1 by cdk inhibitors. AIDS Res Ther. 2010 Mar 24;7(1):7. PMID: 20334651.

Selenica ML, Jensen HS, Larsen AK, et al. Efficacy of small-molecule glycogen synthase kinase-3 inhibitors in the postnatal rat model of tau hyperphosphorylation. Br J Pharmacol. 2007 Nov;152(6):959-79. PMID: 17906685.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • R5700

    Ro 61-8048

    Kynurenine 3-hydroxylase inhibitor.

    ≥99%
  • F465817

    Flunisolide

    Corticosteroid

    ≥90%
  • A985128

    AZD-7648

    DNA-PK inhibitor.

    ≥98%
  • S291333

    Shikonin

    Natural anthraquinone derivative

    ≥98%
  • M0273

    Mastoparan 8

    Antimicrobial peptide found in bee and wasp ven...

    ≥95%
  • P8169

    Purpurin

    Anthraquinone pigment found in madder root; O-a...

    ≥90%
  • D5746

    Dolasetron

    5-HT3 antagonist.

    ≥98%
  • B164094

    Beclomethasone Dipropionate

    Prodrug

    ≥99%
  • L1786

    Levofloxacin Hydrochloride Monohydrate

    Fluoroquinolone, S-(-) isomer of ofloxacin; top...

    ≥90%
  • G8225

    Guggulsterone

    Steroid found in myrrh; FXR antagonist.

    ≥98%
  • F1652

    Fenbufen

    NSAID; COX-1/2 inhibitor.

    ≥98%
  • K040009

    KB-0742 dihydrochloride

    CDK9 inhibitor.

    ≥99%
  • D3329

    7,8-Dihydroxyflavone Hydrate

    TrkB agonist.

    ≥99%
  • A5045

    Amlodipine

    Dihydropyridine, FIASMA; L-type Ca2+ channel bl...

    ≥98%
  • C0266

    Capsaicin, natural

    Found in Capsicum; TRPV agonist.

    ≥95%, capsaicinoids content
  • V1854

    Venlafaxine Hydrochloride

    SERT, NET, MAO inhibitor.

    ≥98%
  • C1635

    Ceftazidime Hydrate

    β-lactam cephalosporin; penicillin binding pro...

    ≥97%
  • T7232

    S-Trityl-L-cysteine

    Organosulfur found in garlic; kinesin Eg5 inhib...

    ≥98%
  • T3202

    Tianeptine

    μOR and δOR agonist, D2/D3 DA potentiator.

    ≥98%
  • S7618

    StemRegenin 1 Hydrochloride

    AhR antagonist.

    ≥98%