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Kendomycin is a cytotoxic macrolide antibiotic that exhibits antibacterial and anticancer activities. Kendomycin induces depolarization of the mitochondrial membrane potential and activates caspase 3, inducing apoptosis in lymphoma cells. Kendomycin inhibits the proteasome and also binds Bcl-xl. Kendomycin is also an antagonist at endothelin receptors.
| Cas No. | 183202-73-5 |
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| Purity | ≥98% |
| Formula | C29H42O6 |
| Formula Wt. | 486.64 |
| IUPAC Name | (1R,9S,10S,12S,14E,16S,19R,20R,21S,22R)-3,9,21-trihydroxy-5,10,12,14,16,20,22-heptamethyl-23,24-dioxatetracyclo[17.3.1.16,9.02,7]tetracosa-2,5,7,14-tetraen-4-one |
| Synonym | (−)-TAN 2162 |
| Solubility | Soluble in DMSO or methanol. |
| Appearance | Yellow powder |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Janssen CO, Lim S, Lo EP, et al. Interaction of kendomycin and semi-synthetic analogues with the anti-apoptotic protein Bcl-xl. Bioorg Med Chem Lett. 2008 Nov 1;18(21):5771-3. PMID: 18845435.
Elnakady YA, Rohde M, Sasse F, et al. Evidence for the mode of action of the highly cytotoxic Streptomyces polyketide kendomycin. Chembiochem. 2007 Jul 23;8(11):1261-72. PMID: 17592829.