LKT Labs

Biochemicals for Life Science Research

Fotemustine

Fotemustine

Product ID F5976
Cas No. 92118-27-9
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $88.10 Please Inquire
25 mg $201.20 Please Inquire
100 mg $503.40 Please Inquire
Bulk Quote

Quicklinks

Description

Fotemustine is a chloroethylnitrosourea that exhibits anticancer chemotherapeutic benefit. Fotemustine alkylates or induces cross-links in DNA, halting cell cycle progression at the G2/M phase and inhibiting DNA repair mechanisms. Fotemustine displays greater cytotoxicity in methyl excision repair-deficient cells, indicating its primary site of alkylation is the O6 site of guanine bases. Fotemustine may also deactivate thioredoxin reductase, glutathione reductase, and ribonucleotide reductase by alkylating their thiol active sites.

Product Info

Cas No.

92118-27-9
Purity

≥98%
Formula

C9H19ClN3O5P
Formula Wt.

315.69
Chemical Name

1-(2-chloroethyl)-3-(1-diethoxyphosphorylethyl)-1-nitrosourea
IUPAC Name

1-(2-chloroethyl)-3-(1-diethoxyphosphorylethyl)-1-nitrosourea
Synonym

Mustophorane; Muphoran
Appearance

Light yellow

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

F5976 MSDS PDF
Info Sheet

F5976 Info Sheet PDF

References

Hayes MT, Bartley J, Parsons PG. In vitro evaluation of fotemustine as a potential agent for limb perfusion in melanoma. Melanoma Res. 1998 Feb;8(1):67-75. PMID: 9508380.

Hayes MT, Bartley J, Parsons PG, et al. Mechanism of action of fotemustine, a new chloroethylnitrosourea anticancer agent: evidence for the formation of two DNA-reactive intermediates contributing to cytotoxicity. Biochemistry. 1997 Sep 2;36(35):10646-54. PMID: 9271495.

Schallreuter KU, Gleason FK, Wood JM. The mechanism of action of the nitrosourea anti-tumor drugs on thioredoxin reductase, glutathione reductase and ribonucleotide reductase. Biochim Biophys Acta. 1990 Aug 13;1054(1):14-20. PMID: 2200526.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • H0001

    H7

    PKC and PKG inhibitor.

    ≥98%
  • T1006

    10-Acetoacetyl Paclitaxel

    Synthesis impurity

    ≥95%
  • G3351

    Ginkgolic Acid (17:1)

    Mixture of alkylphenols found in Ginkgo; HIV pr...

    ≥98%
  • A5327

    Anagrelide

    Imidazoquinazoline; PDE3 inhibitor.

    ≥98%
  • H1794

    Hexamethonium Bromide Hydrate

    Non-depolarizing NMJ blocker; nAChR antagonist....

    ≥98%
  • O2145

    Ofloxacin Hydrochloride

    Fluoroquinolone; topoisomerase IV and bacterial...

    ≥98%
  • T1733

    Teicoplanin

    Glycopeptide, vancomycin analog; peptidoglycan ...

    ≥900 ug/mg, bio assay
  • G1200

    GDC-0068

    Akt inhibitor.

    ≥98%
  • A686164

    Arecaidine Hydrochloride

    mAChR agonist, selective for M2.

    ≥98%
  • P0344

    Palbociclib Isethionate

    CDK4/6 inhibitor.

    ≥98%
  • G4634

    Glipizide

    Sulfonylurea; ATP-sensitive K+ channel blocker....

    ≥98%
  • A7034

    Aripiprazole

    D2 and 5-HT1A partial agonist, 5-HT2C/6/7 antag...

    ≥98%
  • C4517

    Clenbuterol Hydrochloride

    β2-adrenergic agonist.

    ≥98%
  • I1418

    Idebenone

    Synthetic quinone CoQ analog, promotes mitochon...

    ≥98%
  • U682040

    URB597

    FAAH inhibitor.

    ≥98%
  • T3100

    Thyrotropin-releasing Hormone

    Endogenous tripeptide, involved in HPA signalin...

    ≥95%
  • E5568

    Enramycin A

    Polypeptide; peptidoglycan inhibitor.

    ≥95%
  • I7658

    1-Isothiocyanato-9-(methylsulfonyl)-nonane

    Synthetic ITC, erysolin analog.

    ≥98%
  • P5747

    Polymyxin B sulfate

    Cationic lipid polypeptide, mixture of polymyxi...

    ≥6500 iu/mg
  • A0402

    Abacavir Sulfate

    Nucleoside (guanosine) analog; RT, guanylyl cyc...

    ≥98%