LKT Labs

Biochemicals for Life Science Research

AZD-5363

AZD-5363

Product ID A9601
Cas No. 1143532-39-1
Purity ≥99%, ≥99%ee
Product Unit SizeCostQuantityStock
1 mg $87.00 In stock
5 mg $150.00 In stock
25 mg $413.00 In stock
Bulk Quote

Quicklinks

Description

AZD-5363 is an oral pan-AKT inhibitor that causes hyperphosphorylation of AKT, locking it in a catalytically inactive state, unable to phosphorylate downstream signaling substrates such as PRAS40 and GSK-β. This compound displays anticancer chemotherapeutic activity, inhibiting proliferation and inducing tumor regression in in vitro and in vivo models of HER2+ breast cancer and prostate cancer. AZD-5363 may also exhibit inhibitory activity against Rho-associated protein kinase (ROCK), p70S6K, PKA, MKK1, MSK1, MSK2, PKC, PKG, PRKX, and RSK2/3.

Product Info

Cas No.

1143532-39-1
Purity

≥99%, ≥99%ee
Formula

C21H25ClN6O2
Formula Wt.

428.92
Chemical Name

4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2, 3-d]pyrimidin-4-yl)piperidine-4-carboxamide
IUPAC Name

4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2, 3-d]pyrimidin-4-yl)piperidine-4-carboxamide
Synonym

AZD5363
Solubility

In DMSO(86mg/ml), water with 2 eq. of acid, insoulble on ethanol
Appearance

White Crystal Powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

A9601 MSDS PDF
Info Sheet

A9601 Info Sheet PDF
Brochures

PI3K-Akt-mTORC Pathway Booklet

References

Addie M, Ballard P, Buttar D, et al. Discovery of 4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide (AZD5363), an orally bioavailable, potent inhibitor of Akt kinases. J Med Chem. 2013 Mar 14;56(5):2059-73. PMID: 23394218.

Lamoureux F, Thomas C, Crafter C, et al. Blocked autophagy using lysosomotropic agents sensitizes resistant prostate tumor cells to the novel Akt inhibitor AZD5363. Clin Cancer Res. 2013 Feb 15;19(4):833-44. PMID: 23258740.

Davies BR, Greenwood H, Dudley P, et al. Preclinical pharmacology of AZD5363, an inhibitor of AKT: pharmacodynamics, antitumor activity, and correlation of monotherapy activity with genetic background. Mol Cancer Ther. 2012 Apr;11(4):873-87. PMID: 22294718.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • P2410

    Phenethyl Dimethyl Caffeate

    Caffeic acid derivative.

    ≥98%
  • C5870

    Corosolic Acid

    Pentacyclic triterpene found in the Banaba plan...

    ≥98%
  • C691325

    Cridanimod

    STING agonist

    ≥99%
  • R3206

    Riboflavin

    Essential vitamin (B2) found in vegetables, dai...

    ≥97%
  • T7860

    TTP 22

    Casein kinase 2 inhibitor.

    ≥98%
  • D3351

    4-Dimethylaminopyridine

    Acyl transfer catalyst, involved in peptide syn...

    ≥98%
  • T3096

    Thymosin α-1

    Endogenous peptide fragment, immunostimulant; ...

    ≥95%
  • N859614

    NVP-LDE225

    Smo inhibitor.

    ≥98%
  • P4492

    PLX4720

    V600E B-Raf inhibitor.

    ≥98%
  • O9702

    Ozagrel Hydrochloride

    TxA2 synthase inhibitor.

    ≥98%
  • M0374

    Masitinib

    PDGFR and c-Kit inhibitor.

    ≥99%
  • A5326

    Aniracetam

    AMPA positive allosteric modulator, D2, 5-HT2A,...

    ≥98%
  • G7240

    GSK-2830371

    Wip1 inhibitor.

    ≥98%
  • A0922

    Acetyl-L-Carnitine Hydrochloride

    Carnitine derivative, involved in energy homeos...

    ≥98%
  • O486180

    Omeprazole Related Compound A

    Impurity of omeprazole

    ≥99%
  • A4444

    L-Alliin

    Cysteine derivative found in Allium; NMDA NR2A/...

    ≥98%
  • C4457

    Clomipramine Hydrochloride

    FIASMA, mAChR, 5-HT2/3/6/7, α1/2-adrenergic an...

    ≥98%
  • D183738

    19-O-Demethyl rapamycin

    Fermentation impurity

    ≥97%
  • C1609

    Cecropin B

    Antimicrobial peptide found in Hyalophora cecro...

    ≥95%
  • A480020

    (R,S)-AM 1241

    Cannabinoid receptor 2 selective agonist.

    ≥96%